A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

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Summary

It is demonstrated that extracellular adenosine stimulates the A(2A)R to promote long-term T-cell anergy and the generation of adaptive regulatory T cells.

Type
article
Published
2008-01-01
Cited by
525
References
47
Access
Open access

Keywords

Peripheral tolerance, Cell biology, Biology, Immunology, Receptor

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