A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.
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Summary
It is demonstrated that extracellular adenosine stimulates the A(2A)R to promote long-term T-cell anergy and the generation of adaptive regulatory T cells.
- Type
- article
- Published
- 2008-01-01
- Cited by
- 525
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977187462
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24936283
Keywords
Peripheral tolerance, Cell biology, Biology, Immunology, Receptor
References
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- Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.
- In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions1
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- Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E2 axis
- NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.
- CD4+ T-Zell-vermittelte Immunregulation während der Plasmodium yoelii-Infektion
- Caractérisation et suivi chez l’Homme des réponses lymphocytaires T CD4 périphériques spécifiques d’allergènes, naturelles ou induites lors de traitement par immunothérapie allergénique
- The Role of Multiple Cell Types In the Development of Regulatory T-cells
- T regulatory cells and the germinal center
- Phospholipase D Signaling in T Cells
- Die Rolle der Ekto-5'-Nukleotidase (CD73) und des Adenosin-A2A-Rezeptors bei der Immunmodulation
- Rôle de la molécule CD47 dans l’homéostasie du système immunitaire
- In vivo imaging of regulatory T cell mediated transplant tolerance
- Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1
- Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
- Chimiokines et interaction entre l'immunité innée et adaptative dans l'asthme allergique : implication des cellules dendritiques et du récepteur NOD1
- Organ donation and transplantation - public policy and clinical perspectives
- Use of genome wide expression profiles in analysis of T cell dysfunction in Hepatitis C virus infection
- The anti- or pro-inflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environmental-dependent
- Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology
- Immunopathogenic and regulatory leukocyte subsets in juvenile idiopathic arthritis
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