Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
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Summary
It was concluded that clinically manifest Parkinsonism represents the late, "decompensated", stage of a disease characterized by a progressive striatal DA deficiency; and the striatum can compensate functionally for lower degrees of DA deficiency.
- Type
- article
- Published
- 1973-12-01
- Cited by
- 2,793
- References
- 109
- OpenAlex
- https://openalex.org/W1976749972
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31489286
Keywords
Substantia nigra, Parkinsonism, Putamen, Dopamine, Pars compacta
References
- Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere
- The structure and function of nervous tissue
- Die Parkinsonsche Krankheit und ihre Behandlung
- EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
- Assay of serotonin and related metabolites, enzymes, and drugs.
- The basal ganglia and their relation to disorders of movement
- STUDIES OF AMINES IN THE STRIATUM IN MONKEYS WITH NIGRAL LESIONS
- Striatonigral degeneration: Response to levodopa therapy with pathological and neurochemical correlation
- L-dopa therapy in Parkinson's disease: a critical review of nine years' experience.
- The effect of brain stem lesions on tyrosine and tryptophan hydroxylases in various structures of the telencephalon of the cat.
- Caudate Unit Responses to Nigral Stimuli: Evidence for a Possible Nigro-Neostriatal Pathway
- Monoamines in the human neostriatum: topographic distribution in normals and in Parkinson's disease and their role in akinesia, rigidity, chorea, and tremor.
- Topical distribution of the striatal efferents in the monkey
- Electron and fluorescence microscopical studies on the nucleus caudatus putamen of the rat after unilateral lesions of ascending nigro-neostriatal dopamine neurons.
- Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus
- The effects of ventromedial tegmental lesions on the biosynthesis of catecholamines in the striatum
- Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine
- Occurrence and Localization of Catechol Amines in the Human Brain
- CONCENTRIC HYALIN INTRANEURONAL INCLUSIONS OF LEWY TYPE IN THE BRAINS OF ELDERLY PERSONS (50 INCIDENTAL CASES): RELATIONSHIP TO PARKINSONISM
- THE RELEASE IN VIVO OF DOPAMINE SYNTHESIZED FROM LABELLED PRECURSORS IN THE CAUDATE NUCLEUS OF THE CAT
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- Do neuroleptics impair learning in schizophrenic patients?
- Association of Parkinson's disease with symptoms of attention deficit hyperactivity disorder in childhood.
- Exenatide as a novel treatment for Parkinson's Disease
- The motor circuit of the human basal ganglia reconsidered.
- Muscarinic and dopaminergic receptors in the aging human brain.
- The use of pergolide and lisuride, two experimental dopamine agonists, in patients with advanced Parkinson disease.
- Alterations in cognitive performance and affect-arousal state during fluctuations in motor function in Parkinson's disease.
- Age‐Correlated Loss of Dopaminergic Binding Sites in Human Basal Ganglia
- Aromatic L‐amino acid decarboxylase in rat corpus striatum
- Differential effects produced by an anticholinergic on the neuroleptic inhibition of motor behaviour and self-stimulation of the prefrontal cortex in the rat.
- Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions.
- The response to levodopa in parkinson's disease: Imposing pharmacological law and order
- Levodopa biotransformation in hemi-Parkinson rats: effect of dopamine receptor agonists and antagonists.
- Orphan neurones and amine excess: the functional neuropathology of Parkinsonism and neuropsychiatric disease.
- Extrastriatal mean regional uptake of fluorine-18-FDOPA in the normal aged brain--an approach using MRI-aided spatial normalization.
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