Synthesis and In Vivo Antitumor Efficacy of PEGylated Poly(L-lysine) Dendrimer-Camptothecin Conjugates
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Summary
A novel polymer conjugate of CPT using a core-functionalized, symmetrically PEGylated poly(L-lysine) (PLL) dendrimer that showed superior efficacy in murine and human colon carcinoma tumor models when compared with no treatment or treatment with irinotecan.
- Type
- article
- Published
- 2009-07-30
- Cited by
- 142
- References
- 55
- OpenAlex
- https://openalex.org/W1976689981
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22965106
Keywords
Camptothecin, Irinotecan, Conjugate, In vivo, Chemistry
References
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Cited by
- Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation.
- Perspectives on dendritic architectures and their biological applications: From core to cell.
- pH-Responsive Histidine-Rich Elastin-Like Polypeptides That Improve Intratumoral Spatial Distribution
- Flow and Microwave-Assisted Synthesis of N-(Triethylene glycol)glycine Oligomers and Their Remarkable Cellular Transporter Activities.
- Development of New Tools for the Synthesis of "Difficult Peptides"
- Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth
- A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery.
- Improving the Delivery of Camptothecin through the Blood- Brain Barrier via Modulation of Paracellular Pathway using E-Cadherin Peptide
- PAMAM dendrimers: destined for success or doomed to fail? Plain and modified PAMAM dendrimers in the context of biomedical applications.
- Linear–dendritic block copolymers: The state of the art and exciting perspectives
- Novel Dendritic Naproxen Prodrugs with Poly(aspartic Acid) Oligopeptide: Synthesis and Hydroxyapatite Binding in Vitro
- Enhanced bioactivity of internally functionalized cationic dendrimers with PEG cores
- Biological Assessment of Triazine Dendrimers as Candidate Platforms for Nanomedicine: Toxicological Profiles, Solution Behavior, Biodistribution, and Drug Release and Efficacy in a PEGylated, Paclitaxel Construct
- Toxicity and proapoptotic activity of poly(propylene imine) glycodendrimers in vitro: considering their contrary potential as biocompatible entity and drug molecule in cancer.
- Design, synthesis, characterization, and biological evaluation of triazine dendrimers bearing paclitaxel using ester and ester/disulfide linkages.
- G3.5 PAMAM Dendrimers Enhance Transepithelial Transport of SN38 while minimizing Gastrointestinal Toxicity
- Synthesis, Characterization, and Applications of Poly(ethylene glycol)-block-poly(ether-sulfide) Dendrimers
- Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate.
- Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: synthesis, characterization, and antitumor activities.
- New-generation biomedical materials: Peptide dendrimers and their application in biomedicine
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