The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications.
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Summary
A better understanding of the machinery that connects DNA methylation, chromatin and transcriptional activity, in which histone modifications stand in a key position, has been achieved and contributed to understanding how epigenetic deregulation occurs in cancer but also to developing novel therapies that can reverse epigenetic defects in cancer cells.
- Type
- review
- Published
- 2005-09-01
- Cited by
- 45
- References
- 54
- OpenAlex
- https://openalex.org/W72765997
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8833555
Keywords
Epigenetics, Cancer epigenetics, DNA methylation, Biology, Histone
References
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- Drug discovery with engineered zinc-finger proteins
- CpG-binding Protein Is a Nuclear Matrix- and Euchromatin-associated Protein Localized to Nuclear Speckles Containing Human Trithorax
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Cited by
- Rab33A: characterization, expression, and suppression by epigenetic modification.
- Zellbiologische Effekte aktivierter Gerinnungsfaktoren auf Tumorzellen
- Alterations of constitutive pericentromeric heterochromatin in lymphocytes of cancer patients and lymphocytes exposed to 5-azacytidine is associated with DNA-hypomethylation.
- DNA methylation and histone modifications in breast cancer.
- Epigenetische Beeinflussung der Proliferation, Expression von Matrix-Metalloproteinasen, Migration und Invasion von Harnblasenkarzinomzelllinien
- Employing epigenetic marks to detect cancer : studies on nasopharyngeal carcinoma and lung cancer
- Histone lysine methylation in the context of nuclear architecture
- The new frontier in cancer research: deciphering cancer epigenetics.
- An Overview of Epigenetics in Nursing
- Methylation and microRNA-mediated epigenetic regulation of SOCS3
- Epigenetic regulation of mmp-9 gene expression
- MiRNAs, epigenetics, and cancer
- Targeting the epigenome for the treatment of thoracic malignancies.
- Cytosine Methyltransferases as Tumor Markers
- The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes
- Histone H2A.Z deregulation in prostate cancer. Cause or effect?
- Hypermethylation of the ABCB1 downstream gene promoter accompanies ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast tumor cells
- A specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert‐Bazin type) mycosis fungoides
- Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there
- Downregulation of RUNX3 and TES by hypermethylation in glioblastoma
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