Detection of HIV‐1 DNA in Microglia/ Macrophages, Astrocytes and Neurons Isolated from Brain Tissue with HIV‐1 Encephalitis by Laser Capture Microdissection
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Summary
HIV‐1 gag DNA was consistently detected in the frontal cortex and basal ganglia in 1 to 20 p24 HIV‐1 capsid positive cells, and in pools of 50 to 100 microglia/macrophage cells,100 to 200 astrocytes, and 100 to 200 neurons in HIV-1 positive cases but not in HIV‐ 1 negative controls.
- Type
- article
- Published
- 2003-04-01
- Cited by
- 201
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974702421
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12380642
Keywords
Laser capture microdissection, Microglia, Encephalitis, Microdissection, Human immunodeficiency virus (HIV)
References
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- DNA Extraction from Archival Formalin-fixed, Paraffin-embedded Tissue Sections Based on the Antigen Retrieval Principle: Heating Under the Influence of pH
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- Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
- Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
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- HIV Type 1 Infection of Human Cortical Neuronal Cells: Enhancement by Select Neuronal Growth Factors
Cited by
- Proteomic Modeling for HIV-1 Infected Microglia-Astrocyte Crosstalk
- Neuronal toxicity in HIV CNS disease
- Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
- 19 Pathogenesis and Treatment of HIV-associated Dementia: Recent Studies in a SCID Mouse Model
- Immunophilins: new biomarkers and therapeutic targets for neurodegenerative diseases
- RELATIONSHIP BETWEEN SYSTEMIC AND CENTRAL NERVOUS SYSTEM MONOCYTE/MACROPHAGE INFECTION IN SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS
- Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent
- CNS Neural/Glial Progenitors as Targets of HIV-1 and Opiates: Effects on Proliferation and Population Dynamics May Alter Behavior Outcomes.
- ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER
- S100β as a novel and accessible indicator for the presence of monocyte-driven encephalitis in AIDS
- Cloning and characterization of the 3′‐untranslated region of the human excitatory amino acid transporter 2 transcript
- Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes
- Influence of the exogenous virus HIV-1 on the expression of human endogenous retroviral elements (HERVs)
- Imaging Neuroinflammation? A Perspective from MR Spectroscopy
- Epigenetic Regulation of HIV-1 Latency in Astrocytes
- Innate immune responses to HIV infection in the central nervous system
- Gene expression for HIV-associated dementia and HIV encephalitis in microdissected neurons 1: preliminary analysis
- Molecular Pathology of Neuro-AIDS (CNS-HIV)
- HIV–1 Antigens in Neurons of Cocaine-Abusing Patients
- Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.
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