HIV mediates a productive infection of the brain.
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Summary
HIV mediates a productive infection of brain macrophages/microglia and there was no evidence supporting the hypothesis of substantial neuronal or macroglial infection, or evidence of substantial proviral burden prior to the development of productive infection.
- Type
- article
- Published
- 1999-10-22
- Cited by
- 90
- References
- 14
- OpenAlex
- https://openalex.org/W10546857
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38566979
Keywords
Computer science
References
- In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.
- Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection
- Overexpression of nef as a marker for restricted HIV‐1 infection of astrocytes in postmortem pediatric central nervous tissues
- Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndrome
- Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
- Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
- Clinical‐neuropathologic correlation in HIV‐associated dementia
- Brain Viral Burden in HIV Infection
- Distribution of Brain HIV Load in AIDS
- Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome
- Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences
- HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement.
- HIV‐1 infection of subcortical astrocytes in the pediatric central nervous system
- Laboratory Markers of Antiviral Activity
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- Subcortical shape and volume abnormalities in an elderly HIV+ cohort
- Damage and Repair of DNA in HIV Encephalitis
- Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism
- Amygdalae Enlargement and Activation are Associated with Social Network Complexity in Individuals with Human Immunodeficiency Virus (HIV)
- RELATIONSHIP BETWEEN SYSTEMIC AND CENTRAL NERVOUS SYSTEM MONOCYTE/MACROPHAGE INFECTION IN SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS
- HIV AND OPIATES-MEDIATED NEUROTOXICITY: GSK3β IS A POTENTIAL THERAPEUTIC TARGET
- The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis
- Identification by mRNA Differential Display of Two Up-regulated Genes as Candidate Mediators of AIDS Dementia
- Untersuchungen der regulatorischen Eigenschaften der HIV-1 Proteine Rev und Tat in humanen Astrozyten
- Mapping abnormal subcortical brain morphometry in an elderly HIV + cohort
- Cell Cycle Proteins Exhibit Altered Expression Patterns in Lentiviral-Associated Encephalitis
- Assessing the Efficacy of Highly Active Antiretroviral Therapy in the Brain
- Impaired Astrocytes and Diffuse Activation of Microglia in the Cerebral Cortex in Simian Immunodeficiency Virus-Infected Macaques Without Simian Immunodeficiency Virus Encephalitis
- Detection of HIV‐1 DNA in Microglia/ Macrophages, Astrocytes and Neurons Isolated from Brain Tissue with HIV‐1 Encephalitis by Laser Capture Microdissection
- In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases
- Cocaine-mediated enhancement of virus replication in macrophages: Implications for human immunodeficiency virus-associated dementia
- High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS
- Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage‐tropic simian immunodeficiency virus
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