Interaction of Type A Lantibiotics with Undecaprenol-Bound Cell Envelope Precursors
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Summary
It is shown that, besides binding to lipid II, nisin interacts with the lipid intermediates lipid III and lipid IV of the wall teichoic acid (WTA) biosynthesis pathway, which promoted target-mediated pore formation in artificial lipid bilayers.
- Type
- article
- Published
- 2012-06-01
- Cited by
- 62
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974156916
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8380788
Keywords
Lipid II, Lantibiotics, Nisin, Biochemistry, Cell envelope
References
- Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
- Specific Binding of Nisin to the Peptidoglycan Precursor Lipid II Combines Pore Formation and Inhibition of Cell Wall Biosynthesis for Potent Antibiotic Activity*
- In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II‐Gly5) of Staphylococcus aureus
- THE INHIBITING EFFECT OF STREPTOCOCCUS LACTIS ON LACTOBACILLUS BULGARICUS
- Engineering dehydrated amino acid residues in the antimicrobial peptide nisin.
- Role of lipid‐bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics
- Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.
- Surface location and orientation of the lantibiotic nisin bound to membrane-mimicking micelles of dodecylphosphocholine and of sodium dodecylsulphate.
- Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibition.
- Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II
- Mechanism of Action and Limited Cross-Resistance of New Lipopeptide MX-2401
- Lantibiotics: mode of action, biosynthesis and bioengineering.
- The orientation of nisin in membranes.
- Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells.
- A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
- Efflux of low-Mr substances from the cytoplasm of sensitive cells caused by the staphylococcin-like agent Pep 5
- Assembly and stability of nisin-lipid II pores.
- Lantibiotics: diverse activities and unique modes of action.
- Binding of Nisin Z to bilayer vesicles as determined with isothermal titration calorimetry.
- Targeting extracellular pyrophosphates underpins the high selectivity of nisin
Cited by
- New chemical tools to probe cell wall biosynthesis in bacteria.
- An ‘Upp'‐turn in bacteriocin receptor identification
- Peptide Bacteriocins--Structure Activity Relationships.
- Peptide antimicrobials: cell wall as a bacterial target
- Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity.
- Subcellular Proteomics for Understanding Host Defense Peptides Mechanism of Action
- Epidermin and gallidermin: Staphylococcal lantibiotics.
- A new antibiotic kills pathogens without detectable resistance
- The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions*
- Lipid-II forms potential “landing terrain” for lantibiotics in simulated bacterial membrane
- Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance
- Surface Glycosaminoglycans Protect Eukaryotic Cells against Membrane-Driven Peptide Bacteriocins
- The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa
- High-resolution crystal structure reveals molecular details of target recognition by bacitracin
- Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.
- Copsin, a Novel Peptide-based Fungal Antibiotic Interfering with the Peptidoglycan Synthesis*
- Cell Envelope Stress Response in Cell Wall-Deficient L-Forms of Bacillus subtilis
- Lethal Hydroxyl Radical Accumulation by a Lactococcal Bacteriocin, Lacticin Q
- Activity of Gallidermin on Staphylococcus aureus and Staphylococcus epidermidis Biofilms
- Characterization of a Sensory Complex Involved in Antimicrobial Peptide Resistance: Communication Between a Histidine Kinase and an ABC Transporter in Bacillus subtilis
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