Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
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Summary
Elderly study participants were markedly insulin-resistant as compared with young controls, and this resistance was attributable to reduced insulin-stimulated muscle glucose metabolism, which supports the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly.
- Type
- article
- Published
- 2003-05-16
- Cited by
- 2,145
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973842058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40428065
Keywords
Insulin resistance, Internal medicine, Endocrinology, Insulin, Oxidative phosphorylation
References
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- Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
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- Pathophysiology of nonalcoholic steatohepatitis.
- Metabolic risks identified by the combination of enlarged waist and elevated triacylglycerol concentration.
- Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.
- Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
- The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin
- Pathogenesis of non-alcoholic steatohepatitis: human data.
- Enhanced skeletal muscle for effective glucose homeostasis.
- Is adiposopathy (sick fat) an endocrine disease?
- Sirtuins — novel therapeutic targets to treat age-associated diseases
- Novel aspects of adipocyte-induced skeletal muscle insulin resistance
- Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
- The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.
- Diacylglycerol-mediated insulin resistance
- Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly
- Skeletal muscle aging and the mitochondria
- Diabetes in older people: new insights and remaining challenges.
- Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
- Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes
- Effect of mitochondrial stress on systemic metabolism
- Depletion of mitoferrins leads to mitochondrial dysfunction and impairment of adipogenic differentiation in 3T3-L1 preadipocytes
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