Diacylglycerol-mediated insulin resistance
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Summary
Diacylglycerol-mediated insulin resistance is discussed as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 diabetes mellitus, as well as lipodystrophy and aging.
- Type
- article
- Published
- 2010-04-01
- Cited by
- 470
- References
- 58
- OpenAlex
- https://openalex.org/W20376053
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20125083
Keywords
Controller (irrigation), Control engineering, Rapid prototyping, Distributed control system, Computer science
References
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- Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
- Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
- Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance*
- THE GLUCOSE FATTY ACID CYCLE IN OBESITY AND MATURITY ONSET DIABETES MELLITUS
- Insulin resistance. Prosperity's plague.
- Inflammation and metabolic disorders
- Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
- Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
- Obesity is associated with macrophage accumulation in adipose tissue.
- Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis.
- Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease*
- The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
- Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
- Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.
- Inflammation and endoplasmic reticulum stress in obesity and diabetes
- Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM
- Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Cited by
- Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells
- Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model
- Targeting skeletal muscle mitochondria to prevent type 2 diabetes in youth.
- De Novo Lipogenesis Products and Endogenous Lipokines
- iNKT cells prevent obesity-induced hepatic steatosis in mice in a C-C chemokine receptor 7-dependent manner
- Atypical Antipsychotics and the Human Skeletal Muscle Lipidome
- Metabolomic characterization of hypertension and dyslipidemia
- Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
- Mechanisms of disease: Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes.
- Sanye Tablet Ameliorates Insulin Resistance and Dysregulated Lipid Metabolism in High-Fat Diet-Induced Obese Mice
- Mechanism-based discovery of new anti-diabetic drugs from the natural products in traditional Chinese medicine
- Carnitine metabolism and human nutrition
- METABOLIC AND ENDOCRINE ADAPTATIONS TO HEAT STRESS IN LACTATING DAIRY COWS
- Modulation de l’apport en acides gras polyinsaturés n-3 : intérêt chez le sujet sain et au cours de l’insuffisance rénale chronique
- The role of endoplasmic reticulum stress and insulin resistance in the occurrence of goose fatty liver.
- In vivo and in vitro regulation of skeletal muscle lipid metabolism
- Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high-fat-fed mice.
- Efeitos do deidroepiandrosterona (DHEA) sobre a função vascular e a resistência periférica à insulina em um modelo experimental de menopausa.
- Perspectives and Potential Applications of Mitochondria‐Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes
- Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
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