Atp7a determines a hierarchy of copper metabolism essential for notochord development.
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Summary
The findings reveal a role for copper in notochord formation and demonstrate a hierarchy of copper metabolism within the embryo, and suggest that suboptimal copper metabolism may contribute to birth defects.
- Type
- article
- Published
- 2006-08-01
- Cited by
- 129
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973691524
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29628980
Keywords
ATP7A, Menkes disease, Notochord, Zebrafish, Biology
References
- A delicate balance: homeostatic control of copper uptake and distribution.
- Lysyl oxidases: a novel multifunctional amine oxidase family.
- Menkes Copper-Translocating P-type ATPase (ATP7A): Biochemical and Cell Biology Properties, and Role in Menkes Disease
- The zebrafish : cellular and developmental biology
- Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
- Efficient recovery of ENU-induced mutations from the zebrafish germline.
- Effect of copper deficiency on prenatal development and pregnancy outcome.
- Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos.
- Genetic defects in copper metabolism.
- Structure and function of the notochord: an essential organ for chordate development
- The genetic basis of mammalian neurulation
- Small molecule developmental screens reveal the logic and timing of vertebrate development.
- Effective targeted gene ‘knockdown’ in zebrafish
- The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis
- Erythropoiesis in the developing rainbow trout, Salmo gairdneri irideus: histochemical and immunochemical detection of erythropoietic organs.
- In vivo drug discovery in the zebrafish
- Changes in zinc, copper and metallothionein contents during oocyte growth and early development of the teleost Danio rerio (zebrafish).
- Universal GFP reporter for the study of vascular development
- kitb, a second zebrafish ortholog of mouse Kit
- Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
Cited by
- Juxtaposition of chemical and mutation- induced developmental defects in zebrafish reveal a novel copper-chelating activity for kalihinol F
- Mechanisms of Copper-Dependent Notochord Formation in Zebrafish
- Chemical-genetic interrogation of small molecule mechanism of action in S. cerevisiae
- Small molecule screening identifies targetable zebrafish pigmentation pathways
- The Genomic and Physiological Effects of Waterborne Copper Exposure in Zebrafish, Danio Rerio
- Cartilage and bone malformations in the head of zebrafish (Danio rerio) embryos following exposure to disulfiram and acetic acid hydrazide.
- Homeostasis and toxicology of essential metals
- The Establishment and Regulation of Melanocyte Stem Cells in Zebrafish
- Neocuproine Ablates Melanocytes in Adult Zebrafish
- New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease*
- Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein.
- Evolution of Copper Transporting ATPases in Eukaryotic Organisms
- Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disorders.
- The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease.
- Structural organization of human Cu-transporting ATPases: learning from building blocks
- Assembling the pieces.
- Multiple Cu-ATPase genes are differentially expressed and transcriptionally regulated by Cu exposure in sea bream, Sparus aurata.
- Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis
- Interactions of Peptide Amidation and Copper: Novel Biomarkers and Mechanisms of Neural Dysfunction
- BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development.
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