Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
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Summary
Estimates of breast and ovarian cancer risks are provided which are useful for counselling BRCA1-mutation carriers and carriers are at increased risk of colon and prostate cancer, which may be of clinical significance in certain families if the risks are associated with specific mutations.
- Type
- article
- Published
- 1994-03-19
- Cited by
- 1,879
- References
- 9
- OpenAlex
- https://openalex.org/W1973690102
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8338383
Keywords
Ovarian cancer, Breast cancer, Medicine, Oncology, Cancer
References
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- Linkage analysis of chromosome 17q markers and breast-ovarian cancer in Icelandic families, and possible relationship to prostatic cancer.
- THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.
- Familial breast-ovarian cancer locus on chromosome 17q12-q23.
- Dinucleotide repeat polymorphism at the D15S87 locus.
- Intra-abdominal carcinomatosis after prophylactic oophorectomy in ovarian-cancer-prone families.
- Linkage of early-onset familial breast cancer to chromosome 17q21.
- Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.
- Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci
Cited by
- Progress in prostate cancer
- Searches begin and end
- Inherited breast cancer.
- Synchronous elective contralateral mastectomy and immediate bilateral breast reconstruction in women with early-stage breast cancer
- Risk of breast and ovarian cancer in women with strong family histories.
- The Jewish Ashkenazi founder mutations in the BRCA1/BRCA2 genes are not found at an increased frequency in Ashkenazi patients with prostate cancer.
- Issues of Regret in Women With Contralateral Prophylactic Mastectomies
- Testing adolescents for a hereditary breast cancer gene (BRCA1): respecting their autonomy is in their best interest.
- Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.
- Ovarian tissue cryopreservation and gynecologic oncology: a review.
- Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer
- Cancer risks in women with 2 breast or ovarian cancers: Clues to genetic cancer susceptibility
- Effects of genetic consultation on perception of a family risk of breast/ovarian cancer and determinants of inaccurate perception after the consultation.
- Editor's comment: colon cancer carrier screening enters the genetic testing arena.
- Knowledge about breast cancer risk factors and hereditary breast cancer among early-onset breast cancer survivors
- The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews
- Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer
- Ovarian cancer screening and early detection in the general population.
- Oral contraceptives, salpingo-oophorectomy and hormone replacement therapy in BRCA1-2 mutation carriers.
- Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families.
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