Alteration of biopharmaceutical properties of drugs by their conjugation with water-soluble macromolecules: Uricase-dextran conjugate
Explore this paper's citation graph
Summary
Results show that the disposition characteristics of protein drugs also can be altered by conjugation with dextran derivatives, depending on their physicochemical properties.
- Type
- article
- Published
- 1990-01-01
- Cited by
- 33
- References
- 39
- OpenAlex
- https://openalex.org/W1973611826
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83881821
Keywords
Dextran, Conjugate, Chemistry, Macromolecule, Conjugated system
References
- Commentary. Lysosomotropic agents.
- Absorption characteristics of macromolecular prodrugs of mitomycin C following intramuscular administration.
- Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors.
- Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate.
- Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits.
- Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.
- Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol.
- A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
- Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.
- Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration
- Physicochemical properties and antitumor activities of polymeric prodrugs of mitomycin C with different regeneration rates
- Urinary excretion characteristics of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate.
- Covalent linkage of carboxypeptidase G2 to soluble dextrans--I. Properties of conjugates and effects on plasma persistence in mice.
- Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver.
- Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities
- The Accumulation Mechanism of Cationic Mitomycin C‐dextran Conjugates in the Liver: In‐vivo Cellular Localization and In‐vitro Interaction with Hepatocytes
- Chemotherapy through lysosomes with a DNA-daunorubicin complex.
- A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.
- Soluble macromolecular carriers for the delivery of antitumour drugs
- Physiologically based pharmacokinetic modeling: principles and applications.
Cited by
- Disposition Characteristics of Protein Drugs in the Perfused Rat Kidney
- Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver
- Design for Cell-Specific Targeting of Proteins Utilizing Sugar-Recognition Mechanism: Effect of Molecular Weight of Proteins on Targeting Efficiency
- Physico-Chemical and Biological Properties of Monofunctional Hydroxy Teriminating Poly(N-Vinylpyrrolidone) Conjugated Superoxide Dismutase
- Improved Pharmacological Properties for Superoxide Dismutase Modified with Carboxymethycellulose
- Pharmacokinetics of receptor-mediated hepatic uptake of glycosylated albumin in mice
- Synthesis and characterization of an acylated di-peptide (Myr-Trp-Leu) with modified transmucosal transport properties.
- Polymer Conjugates
- Modification of physico-chemical and biopharmaceutical properties of superoxide dismutase by conjugation to the co-polymer of divinyl ether and maleic anhydride
- Control of the disposition profiles of proteins in the kidney via chemical modification
- Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids : synergistic effects of acylation and absorption enhancers
- In vitro cytotoxicity of macromolecules in different cell culture systems
- Targeting Delivery of Protein Drugs by Chemical Modification
- Stabilization of α-amylase by chemical modification with carboxymethylcellulose
- Functional peptide-polyurethane conjugates with extended circulatory half-lives.
- Pharmacokinetics of succinylated proteins and dextran sulfate in mice : implications for hepatic targeting of protein drugs by direct succinylation via scavenger receptors
- Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine).
- Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol.
- Dextrans for targeted and sustained delivery of therapeutic and imaging agents.
- Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion.
Related papers
- Studies of Reversible Conjugate Additions
- Fluctuation and linkage relations in macromolecular solution
- Preparation of Soy Protein-Dextran Conjugate Through the Maillard Reaction
- A dextran-platinum(iv) conjugate as a reduction-responsive carrier for triggered drug release.
- Aldehyde–dextran–protein conjugates to immobilize amino-haptens: avoiding cross-reactions in the immunodetection
- Conjugate chemistry and cellular processing of EGF-dextran.
- Glucose Oxidase-dextran Conjugates with Enhanced Stabilities Against Temperature and pH
- New antibody purification procedure using a thermally responsive poly(N-isopropylacrylamide)-dextran derivative conjugate.