Physico-Chemical and Biological Properties of Monofunctional Hydroxy Teriminating Poly(N-Vinylpyrrolidone) Conjugated Superoxide Dismutase
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Summary
All the polymer-enzyme conjugates showed increased body residence time after intravenous injection in rats with respect to the native enzyme, and PVP was found to affect the pharmacokinetic properties of the enzyme after subcutaneous, intramuscular and intraperitoneal administration.
- Type
- article
- Published
- 1995-04-01
- Cited by
- 43
- References
- 23
- OpenAlex
- https://openalex.org/W1672177187
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83548145
Keywords
Chemistry, Superoxide dismutase, Antigenicity, Solubility, Denaturation (fissile materials)
References
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- Determination of serum proteins by means of the biuret reaction.
- PREPARATION, PHYSICO-CHEMICAL AND PHARMACOKINETIC CHARACTERIZATION OF MONOMETHOXYPOLY(ETHYLENE GLYCOL)- DERIVATIZED SUPEROXIDE DISMUTASE
- Alteration of biopharmaceutical properties of drugs by their conjugation with water-soluble macromolecules: Uricase-dextran conjugate
- Low Molecular Weight End-Functionalized Poly(N-Vinylpyrrolidinone) for the Modification of Polypeptide Aminogroups
- Inhibition of stress-induced gastric mucosal injury by a long acting superoxide dismutase that circulates bound to albumin.
- Characterization of the heterogeneity of polyethylene glycol-modified superoxide dismutase by chromatographic and electrophoretic techniques.
- The suppressive effect of gelatin‐conjugated superoxide dismutase on disease development and severity of collagen‐induced arthritis in mice
- Suppression of IgE antibodies to the (4‐hydroxy‐3‐iodo‐5‐nitrophenyl)acetyl (NIP) group and induction of NIP‐specific suppressor cells with NIP‐poly‐N‐vinylpyrrolidone conjugates
- Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.
- Conjugation of Cu,Zn-superoxide dismutase with succinylated gelatin: pharmacological activity and cell-lubricating function.
- The therapeutic value of poly(ethylene glycol)-modified proteins
- A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts.
- Enzyme modification by MPEG with an amino acid or peptide as spacer arms
- Preparation and properties of trypsin and chymotrysin coupled covalently to poly (N-vinylpyrrolidone).
- Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol.
- Polymeric pseudolatices bearing pilocarpine for controlled ocular delivery.
Cited by
- Enzyme therapeutics for systemic detoxification.
- Design of oxidation-sensitive polymer micelles for inflammation targeting
- Improved Pharmacological Properties for Superoxide Dismutase Modified with Carboxymethycellulose
- Synthesis and pharmacokinetic behaviour of ester derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen) with end-hydroxylated poly(N-vinyl pyrrolidinone) and poly(N-acryloyl morpholine) oligomers.
- PEG - a versatile conjugating ligand for drugs and drug delivery systems.
- Modification of physico-chemical and biopharmaceutical properties of superoxide dismutase by conjugation to the co-polymer of divinyl ether and maleic anhydride
- Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates
- Effect of Grafted Amphiphilic PVP-Palmityl Polymers on the Thermotropic Phase Behavior of 1,2 Dipalmitoyl- sn-glycero-3-phosphocholine Bilayer.
- Improved pharmacological properties for superoxide dismutase modified with β-cyclodextrin–carboxymethylcellulose polymer
- Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation.
- Improvement of Drug Therapy by Covalent PEG Conjugation: An Overview From a Research Laboratory
- Glycosidation of cu,zn-superoxide dismutase with end-group aminated dextran: pharmacological and pharmacokinetics properties.
- Artificial cell containing superoxide dismutase--selection of folding aids for stabilisation of SOD.
- Functionalization and molecular dynamics study of carboxy‐terminated poly(1‐vinylpyrrolidin‐2‐one): A potential soluble carrier of biomolecules
- Synthesis and Properties of Poly[N-(2-Hydroxypropyl) Methacrylamide] Conjugates of Superoxide Dismutase
- Pharmacokinetics and Stability Properties of Catalase Modified with Water‐Soluble Polysaccharides
- Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen
- Improved Pharmacokinetics Properties for Catalase by Site-Specific Glycosidation with Aminated Dextran
- Peptide and protein PEGylation: a review of problems and solutions.
- Ferrocene derivatives supported on poly (N -vinylpyrrolidin -2 -one) (PVP) : Synthesis of new water-soluble electrochemically active probes for biomolecules
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