A FADD-dependent innate immune mechanism in mammalian cells
Explore this paper's citation graph
Summary
It is reported that mammalian cells lacking the death-domain-containing protein FADD are defective in intracellular dsRNA-activated gene expression, including production of type I (α/β) interferons, and are thus very susceptible to viral infection.
- Type
- article
- Published
- 2004-11-18
- Cited by
- 318
- References
- 31
- OpenAlex
- https://openalex.org/W1973472843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1400571
Keywords
Innate immune system, Biology, FADD, Cell biology, Protein kinase R
References
- Signalling: STATs: transcriptional control and biological impact
- IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
- Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
- FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
- The immune response of Drosophila
- TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
- Toll-like receptors.
- Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection.
- PKR; a sentinel kinase for cellular stress
- Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults.
- JNK2 and IKKbeta are required for activating the innate response to viral infection.
- Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
- Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
- FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
- Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
- The Toll receptor family and microbial recognition.
- Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway
- How cells respond to interferons.
- The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection
- Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
Cited by
- Interferon gene regulation: not all roads lead to Tolls.
- Personalizing oncolytic virotherapy?
- Recognition of viral nucleic acids in innate immunity
- Interferon-γ-Induced Necrosis: An Antitumor Biotherapeutic Perspective
- Immune evasion strategies of molluscum contagiosum virus.
- XIAP promotes the innate immune response during cytosolic bacterial infection
- A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina
- NF-κB and the immune response
- Anti-viral tetris: modulation of the innate anti-viral immune response by A20.
- Negative regulation of host innate antiviral signaling
- Critical Contribution of RAL GTPases to Growth and Survival of Breast Cancer Cells
- INHIBITION OF HOST INNATE IMMUNE RESPONSES THROUGH THE MODULATION OF CYTOPLASMIC STRESS GRANULES BY ENCEPHALOMYOCARDITIS VIRUS PROTEASE
- Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation
- Caractérisation de la voie d'activation des interférons de type I
- Le rôle de l’ubiquitination et des endomembranes dans l’activation du facteur de transcription NF-κB
- Caspase Mediated Cleavage, IAP Binding, Ubiquitination and Kinase Activation : Defining the Molecular Mechanisms Required for Drosophila NF-кB Signaling: A Dissertation
- Induction of CYR61 by Oncolytic HSV Infection of Glioma
- Plasma Pattern Recognition Receptors of Walleye (Sander vitreus M.) with an Emphasis on Mannose-binding Lectin-Like Protein and Viral Hemorrhagic Septicemia Virus
- Defective interfering particles of parainfluenza virus subtype 5 and interferon induction
- NF-κB and innate immunity.
Related papers
- PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
- The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-α receptors
- Innate sensing of viruses by pattern recognition receptors in birds
- PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling
- IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation
- The intersection molecule MDA5 in Cancer and COVID-19
- Sensing of viral nucleic acids by RIG-I: from translocation to translation
- Molecular Mechanisms of Viral RNA Detection: RIG-I and MDA5