Gadd45a Is an RNA Binding Protein and Is Localized in Nuclear Speckles
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Summary
It is shown that Gadd45a binds RNA but not single- or double stranded DNA or methylated DNA in vitro, which suggests that RNA binding is not absolutely essential for demethylation of an artificial substrate and suggests that Gaddy45a is associated with a ribonucleoprotein particle.
- Type
- article
- Published
- 2011-01-07
- Cited by
- 57
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972975172
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1684287
Keywords
RNA, Biology, Small nuclear RNA, Molecular biology, DNA demethylation
References
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- Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin
- Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
- Gemcitabine Functions Epigenetically by Inhibiting Repair Mediated DNA Demethylation
- Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.
- Non-coding RNA directed DNA demethylation of Sphk1 CpG island.
- Interaction of CR6 (GADD45γ) with Proliferating Cell Nuclear Antigen Impedes Negative Growth Control*
- A chicken embryo protein related to the mammalian DEAD box protein p68 is tightly associated with the highly purified protein-RNA complex of 5-MeC-DNA glycosylase.
- Structure-function relationships of Toll-like receptor domains through homology modelling and molecular dynamics.
- TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.
- Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells.
- The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.
- Nuclear speckles: a model for nuclear organelles
- Human DNA‐demethylating activity: A glycosylase associated with RNA and PCNA
- Characterization of MyD118, Gadd45, and Proliferating Cell Nuclear Antigen (PCNA) Interacting Domains
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling
- DNA demethylation in vitro: involvement of RNA.
- Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines
- Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs.
- Comprehensive modeling and functional analysis of Toll‐like receptor ligand‐recognition domains
Cited by
- Gadd45 proteins: key players of repair-mediated DNA demethylation.
- Gadd45 in the liver: signal transduction and transcriptional mechanisms.
- Gadd45 in modulation of solid tumors and leukemia.
- Gadd45 Stress Sensor Genes
- Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress
- Mammalian DNA demethylation
- The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance
- Mismatch-mediated error prone repair at the Immunoglobulin genes
- Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.
- Active DNA demethylation by Gadd45 and DNA repair.
- Abnormal Levels of Gadd45alpha in Developing Neocortex Impair Neurite Outgrowth
- GADD45A (growth arrest and DNA-damage-inducible, alpha)
- Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy*
- Epigenetically regulated microRNAs in Alzheimer's disease.
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair
- Gadd45 proteins: Relevance to aging, longevity and age-related pathologies
- Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.
- Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model.
- The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL
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