Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin
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Summary
It is demonstrated that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing and cleavage activity in the presence of core histones, implying that Gaddy45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins.
- Type
- article
- Published
- 1999-03-01
- Cited by
- 290
- References
- 83
- Access
- Open access
- OpenAlex
- https://openalex.org/W1918117223
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10560255
Keywords
Biology, Histone, Chromatin, Nucleosome, Acetylation
References
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- DNA repair : a laboratory manual of research procedures
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- Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II
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- Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene
- Characterisation of the interaction between PCNA and Gadd45.
Cited by
- The specific activation of gadd45 following UVB radiation requires the POU family gene product N-oct3 in human melanoma cells
- The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair
- Critical role of the JNK‐p53‐GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons
- Opening of chloride channels by 1α,25-dihydroxyvitamin D3 contributes to photoprotection against UVR-induced thymine dimers in keratinocytes.
- Gadd45 proteins: key players of repair-mediated DNA demethylation.
- Epigenetic Mechanisms in Schizophrenia
- Gadd45 in stress signaling, cell cycle control, and apoptosis.
- The GADD45a-GFP GreenScreen HC assay.
- Dynamics of DNA methylation in differentiating hematopoietic cells
- The Regulation of Cellular Stress Resistance and DNA Repair in a Long-Lived Mutant Mouse.
- The effects of leptomycin B on HPV-infected cells
- The p53 tumor suppressor: Critical regulator of life & death in cancer
- Oxidative stress on mammalian cell cultures during recombinant protein expression
- Genome wide analysis of dna repair by expression profiling
- The complexity of radiation stress responses: analysis by informatics and functional genomics approaches.
- Chromatin perturbations during the DNA damage response in higher eukaryotes
- Up-regulation of Gadd45α after Exposure to Metal Nanoparticles: the Role of Hypoxia Inducible Factor 1α
- Stress sensor Gadd45 genes as therapeutic targets in cancer
- The “Two faces” of Tumor Suppressor p53-revisited
- INTERACTIONS BETWEEN PROTEINS AND IDENTIFICATION OF HIGH AFFINITY ANTAGONISTS
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