Cu(II)-catalyzed direct and site-selective arylation of indoles under mild conditions.
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Summary
A new site-selective Cu(II)-catalyzed C-H bond functionalization process that can selectively arylate indoles at either the C3 or C2 position under mild conditions is developed and tolerates broad functionality on both the indole and aryl unit.
- Type
- article
- Published
- 2008-06-11
- Cited by
- 646
- References
- 3
- OpenAlex
- https://openalex.org/W1972836172
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:197297781
Keywords
Chemistry, Indole test, Aryl, Catalysis, Electrophile
References
Cited by
- A palladium-catalyzed oxidative cycloaromatization of biaryls with alkynes using molecular oxygen as the oxidant.
- Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes.
- Copper-catalyzed carboarylation of alkynes via vinyl cations.
- "On water", phosphine-free palladium-catalyzed room temperature C-H arylation of indoles.
- Tandem C-2 functionalization-intramolecular azide-alkyne 1,3-dipolar cycloaddition reaction: a convenient route to highly diversified 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4]diazepines.
- Copper-catalyzed intermolecular C-H amination of (hetero)arenes via transient unsymmetrical λ³-iodanes.
- Cu(II)-Mediated C(sp(2))-H Hydroxylation.
- (18)F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography.
- Cu-Catalyzed π-Core Evolution of Benzoxadiazoles with Diaryliodonium Salts for Regioselective Synthesis of Phenazine Scaffolds.
- Catalytic Applications of Copper Species in Organic Transformations: A Review
- Cobalt(III)-Catalyzed C2-Selective C-H Alkynylation of Indoles.
- Metal-free N-arylation of secondary amides at room temperature.
- Dual Catalysis in Domino N‐Benzylation/Intramolecular C–H Arylation: Regio‐ and Chemoselective Synthesis of Annelated Nitrogen Heterocycles
- Access to 3‐Arylindoles through a Tandem One‐Pot Protocol Involving Dearomatization, a Regioselective Michael Addition Reaction, and Rearomatization
- Palladium and copper catalysis in regioselective, intermolecular coupling of C-H and C-Hal bonds.
- Palladium-Catalyzed Direct Arylation of Polyfluoroarenes with Organosilicon Reagents
- Pd-catalyzed C-H bond functionalization on the indole and pyrrole nucleus.
- Transition Metal-Catalyzed CH Activation of Indoles
- Pd(OAc)2/AgOAc Catalytic System Based Bidentate Ligand Directed Regiocontrolled C–H Arylation and Alkylation of the C‐3 Position of Thiophene‐ and Furan‐2‐carboxamides
- Arylation with Diaryliodonium Salts.
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