Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice
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Summary
Results demonstrate that Nec-1 prevents ConA-induced liver injury via RIP1-related and autophagy-related pathways.
- Type
- article
- Published
- 2013-10-01
- Cited by
- 90
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972680277
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13996657
Keywords
Concanavalin A, Blot, Immunofluorescence, Liver injury, Molecular biology
References
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- IL-22-Dependent Attenuation of T Cell-Dependent (ConA) Hepatitis in Herpes Virus Entry Mediator Deficiency 1
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- Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice
- The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice
- Interleukin‐15 prevents concanavalin A‐induced liver injury in mice via NKT cell‐dependent mechanism
- Autophagy fights disease through cellular self-digestion
- Necroptosis as an alternative form of programmed cell death
- Role of sinusoidal endothelial cells of the liver in concanavalin A‐induced hepatic injury in mice
- Autophagic programmed cell death by selective catalase degradation.
- Lectins as cell recognition molecules.
- The anticarcinogenic potential of soybean lectin and lunasin.
- RIP kinases at the crossroads of cell death and survival.
- Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.
- The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore
- Midzonal necrosis of the liver after concanavalin A-injection.
- Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury
- Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
- Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
Cited by
- Metabolism of glycerophospholipid, bile acid and retinol is correlated with the early outcomes of autoimmune hepatitis.
- RIP1-Dependent Programmed Necrosis is Negatively Regulated by Caspases During Hepatic Ischemia-Reperfusion
- RIP1 Inhibition Rescues from LPS-Induced RIP3-Mediated Programmed Cell Death, Distributed Energy Metabolism and Spatial Memory Impairment
- Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
- Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis
- Combination therapy of bezafibrate and ursodeoxycholic acid for primary biliary cirrhosis: A meta‐analysis
- Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury
- The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases
- Chloroquine rescues A549 cells from paraquat-induced death
- Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
- N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway
- Necrosis-Dependent and Independent Signaling of the RIP kinases in Inflammation
- The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver
- Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways
- Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy
- Paeoniflorin protects against concanavalin A-induced hepatitis in mice.
- The effect of 4α,5α-epoxy-10α,14-dihydro-inuviscolide, a novel immunosuppressant isolated from Carpesium abrotanoides, on the cytokine profile in vitro and in vivo.
- Ethyl Pyruvate Pretreatment Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice
- Tonsil-derived mesenchymal stem cells alleviate concanavalin A-induced acute liver injury.
- Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
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