Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
Explore this paper's citation graph
Summary
In conclusion, necroptosis is increased in the liver of NAFLD patients and in experimental models of NASH, and RIP3 deficiency attenuated MCD diet-induced liver injury, steatosis, inflammation, fibrosis and oxidative stress.
- Type
- article
- Published
- 2015-10-01
- Cited by
- 206
- References
- 48
- OpenAlex
- https://openalex.org/W1035050697
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26005440
Keywords
Necroptosis, Steatohepatitis, Steatosis, Oxidative stress, Fatty liver
References
- Apoptosis and Necrosis in the Liver
- Rapid synergistic interaction between thyroid hormone and carbohydrate on mRNAS14 induction.
- Toll-Like Receptors in Alcoholic Liver Disease, Non-Alcoholic Steatohepatitis and Carcinogenesis
- Biomarkers of liver cell death.
- Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice
- Efficient recovery of proteins from multiple source samples after trizol® or trizol®LS RNA extraction and long-term storage
- FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
- Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.
- Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
- The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
- Hepatocyte caspase‐8 is an essential modulator of steatohepatitis in rodents
- Hepatocyte Death: A Clear and Present Danger
- Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis
- Nonalcoholic steatohepatitis
- Gene expression of tumor necrosis factor α and TNF‐receptors, p55 and p75, in nonalcoholic steatohepatitis patients
- Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis*
- Positive and Negative Phosphorylation Regulates RIP1 and RIP3-Induced Programmed Necrosis
- MITOCHONDRIAL GSH DETERMINES THE TOXIC OR THERAPEUTIC POTENTIAL OF SUPEROXIDE SCAVENGING IN STEATOHEPATITIS
- Pathogen subversion of RIP3-dependent necrosis
- Cyclophilin A release as a biomarker of necrotic cell death
Cited by
- Mechanism and disease implications of necroptosis and neuronal inflammation
- Innate immunity and inflammation in NAFLD/NASH
- Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
- Necroptosis: Mechanisms and Relevance to Disease
- Receptor Interacting Protein 3 Protects Mice from High Fat Diet-Induced Liver Injury
- The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance
- Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis
- Molecular Pathogenesis of NASH
- The inflammatory signal adaptor RIPK3: functions beyond necroptosis
- Activation of necroptosis in human and experimental cholestasis
- Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease
- Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability.
- Questions and controversies: the role of necroptosis in liver disease
- Liver inflammation and fibrosis.
- Mechanisms of RIPK3‐induced inflammation
- miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
- The in vivo evidence for regulated necrosis
- Evidence of necroptosis in hearts subjected to various forms of ischemic insults.
- Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis
- Proteolytic control of regulated necrosis.
Related papers
- Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease.
- STUDY OF CELL MODELS OF HEPG2 STEATOSIS AND STEATOHEPATITIS VIABILITY
- Are Steatosis and Steatohepatitis Triggers of Hepatic Fibrogenesis
- 1232 XANTHOHUMOL IMPROVES GLUCOSE TOLERANCE AND INHIBITS HEPATIC STEATOSIS, INFLAMMATION AND FIBROGENESIS IN A MURINE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS
- Immunologic abnormalities in alcoholic hepatitis.
- Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease.
- Su313 THE FREQUENCY AND IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOLIC HEPATITIS AND ALCOHOLIC LIVER CIRRHOSIS