The Antioxidant (–)-Epigallocatechin-3-gallate Inhibits Rat Hepatic Stellate Cell Proliferation in Vitro by Blocking the Tyrosine Phosphorylation and Reducing the Gene Expression of Platelet-derived Growth Factor-β Receptor*
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Summary
The inhibitory effect of the natural antioxidant, its long history of beverage consumption without adverse health effects, and higher potent antioxidant capability make it a good candidate for therapeutic treatment and prevention of hepatic fibrosis.
- Type
- article
- Published
- 2003-06-27
- Cited by
- 87
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972676329
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45671113
Keywords
Platelet-derived growth factor receptor, Tyrosine phosphorylation, Hepatic stellate cell, Chemistry, In vitro
References
- Intracellular signaling pathways involved in acetaldehyde‐induced collagen and fibronectin gene expression in human hepatic stellate cells
- Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr (VI)-induced DNA damage and Cr (IV)- or TPA-stimulated NF-κB activation
- Platelet-derived growth factor receptor signals.
- Tea polyphenols: prevention of cancer and optimizing health.
- UV Irradiation Activates JNK and Increases αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells*
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
- Isolation and characterization of the mouse PDGF beta-receptor promoter.
- Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array.
- Green tea polyphenols and cancer: biologic mechanisms and practical implications.
- Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents.
- Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.
- Hepatic fibrosis as wound repair: A progress report
- Conservation in sequence and affinity of human and rodent PDGF ligands and receptors.
- Epigallocatechin gallate inhibits histamine release from rat basophilic leukemia (RBL-2H3) cells: role of tyrosine phosphorylation pathway.
- The biology of oxygen radicals.
- Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells.
- Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver.
- Signal transduction via platelet-derived growth factor receptors.
- Hepatic Stellate Cell Proliferation is an Early Platelet-Derived Growth Factor-Mediated Cellular Event in Rat Cholestatic Liver Injury
- Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury*
Cited by
- Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro.
- Characterization of the AP-1 and NF-kappa B transcription factors in the U-87 astrocytoma cell line
- A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives
- Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90.
- Methyl Gallate from Galla rhois Successfully Controls Clinical Isolates of Salmonella Infection in Both In Vitro and In Vivo Systems
- Antioxidant Activity in Plasma and Tissues Distribution of (-)-Epigallocatechin Gallate after Oral Administration to Rats
- Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury.
- The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats
- Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats.
- Perfecting the plate: adding cardioprotective compounds to the diet.
- Pancreatic stellate cells: New target in the treatment of chronic pancreatitis
- Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet‐derived growth factor‐induced proliferation of the human hepatic stellate cell line LI90
- The phyto-chemical (-)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1.
- The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro
- Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways
- Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.
- Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells
- Alleviation of dimethylnitrosamine-induced liver injury and fibrosis by betaine supplementation in rats.
- Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.
- Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress
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