CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Explore this paper's citation graph
Summary
In vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lenti-virus-, or particle-mediated delivery of guide RNA in neurons, immune cells, and endothelial cells is demonstrated.
- Type
- article
- Published
- 2014-09-01
- Cited by
- 1,894
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972476556
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:131533
Keywords
CRISPR, Biology, Cas9, Genome editing, Guide RNA
References
- Aicardi–Goutieres syndrome: from patients to genes and beyond
- NIH Image to ImageJ: 25 years of Image Analysis
- A high throughput Chromatin ImmunoPrecipitation approach reveals principles of dynamic gene regulation in mammals
- Dendritic cells: specialized and regulated antigen processing machines.
- Manipulating the mouse embryo: A laboratory manual
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
- Conditional control of gene expression in the mouse
- Genetic screens in human cells using the CRISPR/Cas9 system
- Introduction to Genetic Analysis
- Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases.
- Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae.
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
- MDA5 assembles into a polar helical filament on dsRNA
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
- Effect of genome size on AAV vector packaging.
- High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
- RNAi screens in mice identify physiological regulators of oncogenic growth
- Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors
- Cerebrospinal fluid pterins and folates in Aicardi-Goutières syndrome
Cited by
- The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis
- Nanomedicine-mediated cancer stem cell therapy.
- A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors
- Gene editing technology as an approach to the treatment of liver diseases
- A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors
- CRISPR/Cas9 for cancer research and therapy.
- Applications of CRISPR systems in respiratory health: Entering a new ‘red pen’ era in genome editing
- Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice
- Understanding Cancer Mutations by Genome Editing
- The Application of Genome Editing in Studying Hearing Loss
- Somatic CRISPR/Cas9-mediated tumor suppressor disruption enables versatile brain tumor modeling
- Structural and Functional Characterization of the MBD2-NuRD Co-Repressor Complex
- Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity.
- Genetic Discoveries Drive Molecular Analyses and Targeted Therapeutic Options in the Epilepsies
- Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries
- Applications of CRISPR-Cas9 mediated genome engineering
- Organ cooling in liver transplantation and resection: How low should we go?
- Cutting short the path to murine liver cancer models
- Translational value of mouse models in oncology drug development
- A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells
Related papers
- Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency
- Temperature effect on CRISPR-Cas9 mediated genome editing.
- CRISPR/Cas9 system: A promising technology for the treatment of inherited and neoplastic hematological diseases
- Therapeutic applications of CRISPR RNA-guided genome editing.
- Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish
- Chemical transformation mediated CRISPR/Cas9 genome editing in Escherichia coli
- CRISPR/Cas in genome defense and gene editing
- Virus-Based CRISPR/Cas9 Genome Editing in Plants.
- CRISPR-Cas9 technology: applications and human disease modelling.
- Generation of Genome-Edited Mice by Cytoplasmic Injection of CRISPR-Cas9 RNA.