Structural dynamics of the aminoacylation and proof-reading functional cycle of bacterial leucyl-tRNA synthetase
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Summary
Cocrystal structures of the Escherichia coli LeuRS–tRNALeu complex in the aminoacylation or editing conformations are reported, showing that translocation involves correlated rotations of four flexibly linked Leu RS domains.
- Type
- article
- Published
- 2012-06-10
- Cited by
- 145
- References
- 48
- OpenAlex
- https://openalex.org/W1972101882
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:939285
Keywords
Aminoacylation, Proofreading, Transfer RNA, T arm, Biology
References
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- Automated protein model building combined with iterative structure refinement
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- Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalyst.
- The 2 Å crystal structure of leucyl‐tRNA synthetase and its complex with a leucyl‐adenylate analogue
- An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site
- Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
- Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites
Cited by
- Emergence and Evolution
- Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
- Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate.
- Drugging tRNA aminoacylation
- Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases.
- Synthetic and editing mechanisms of aminoacyl-tRNA synthetases.
- Single-Molecule Studies Of Local And Global Nucleic-Acid Dynamics
- Role of Coupled Dynamics and a Strictly Conserved Lysine Residue in the Function of Bacterial Prolyl-tRNA Synthetase and Substrate Binding by a Related trans -Editing Enzyme ProXp-ala
- In Vitro/In Vivo Production of tRNA for X-Ray Studies.
- CP1 domain of leucyl-tRNA synthetase: dissecting its dual roles in amino acid editing and RNA splicing
- Structure and function of the T-loop structural motif in non-coding RNAs
- tRNA synthetase: tRNA Aminoacylation and beyond
- MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery
- EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways
- A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
- Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
- The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments.
- The tRNA A76 Hydroxyl Groups Control Partitioning of the tRNA-dependent Pre- and Post-transfer Editing Pathways in Class I tRNA Synthetase*
- Recognition of tRNAs with a long variable arm by aminoacyl-tRNA synthetases
- The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation
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