Noise Minimization in Eukaryotic Gene Expression

Hunter B. Fraser, Aaron E. Hirsh, Guri Giaever, Jochen Kumm, Michael B. Eisen · PLoS Biology · 2004

Summary

The hypothesis that noise in gene expression is a biologically important variable, is generally detrimental to organismal fitness, and is subject to natural selection is supported.

Type: article
Published: 2004-04-27
Cited by: 448
References: 26
Access: Open access
DOI: https://doi.org/10.1371/journal.pbio.0020137
PubMed: https://pubmed.ncbi.nlm.nih.gov/15124029/
PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/400249/
OpenAlex: https://openalex.org/W1970970926
Semantic Scholar: https://api.semanticscholar.org/CorpusID:1248136

Keywords

Biology, Gene, Saccharomyces cerevisiae, Genetics, Organism

References

Genomic function (communication arising): Rate of evolution and gene dispensabilityCsaba Pál, Balázs Papp, Laurence D. Hurst — 2003
Protein dispensability and rate of evolutionAaron E. Hirsh, Hunter B. Fraser — 2001
Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells.Adam P. Arkin, John Ross, Harley H. McAdams — 1998
Nanoelectromechanical systems: Nanodevice motion at microwave frequenciesXue Huang, Christian A. Zorman, Mehran Mehregany — 2003
Regulation of noise in the expression of a single geneErtuğrul M. Özbudak, Mukund Thattai, Iren Kurtser — 2002
A model for the statistical fluctuations of protein numbers in a microbial population.Otto G. Berg — 1978
Intrinsic noise in gene regulatory networksMukund Thattai, Alexander van Oudenaarden — 2001
Evolutionary Rate in the Protein Interaction NetworkHunter B. Fraser, Aaron E. Hirsh, Lars M. Steinmetz — 2002
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryYuen Ho, Albrecht Gruhler, Adrian Heilbut — 2002
Genomic function (communication arising): Rate of evolution and gene dispensabilityAaron E. Hirsh, Hunter B. Fraser — 2003
Dosage sensitivity and the evolution of gene families in yeastBalázs Papp, Csaba Pál, Laurence D. Hurst — 2003
Playing Dr Jekyll and Mr Hyde: combined mechanisms of phase variation in bacteria.Bernard Hallet — 2001
Noise in eukaryotic gene expressionWilliam J. Blake, Mads Kærn, Charles R. Cantor — 2003
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.Guri Giaever, Patrick Flaherty, Jochen Kumm — 2004
Functional organization of the yeast proteome by systematic analysis of protein complexesAnne‐Claude Gavin, Markus Bösche, Roland Krause — 2002
Comparative assessment of large-scale data sets of protein–protein interactionsChristian von Mering, Roland Krause, ‎Berend Snel — 2002
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiaeYoav Arava, Yulei Wang, John D. Storey — 2003
Lethality and centrality in protein networksHawoong Jeong, S. P. Mason, Albert-Ĺaszló Barabási — 2001
Highly expressed genes in yeast evolve slowly.Csaba Pál, Balázs Papp, Laurence D. Hurst — 2001
Precision and functional specificity in mRNA decayYulei Wang, Chih Long Liu, John D. Storey — 2002

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A dormancy state in nonspore-forming bacteriaChristine Räisänen, Martin Löwstedt — 2009
DNA methylation and transcriptional noiseHector Berlioz — 2013
Links between evolutionary processes and phenotypic robustness in microbes.育代益子, 朋美赤田, 晃赤澤 — 2019
Balancing noise and plasticity in gene expressionDjordje Bajić, Juan F. Poyatos — 2011
Stochasticité de l'expression génique et régulation transcriptionnelle - Modélisation de la dynamique spatiale et temporelle des structures multiprotéiques. (Stochasticity of gene expression and transcriptional regulation - Modeling the spatial and temporal dynamics of multiprotein structures)Antoine Coulon — 2010
Evolutionary Systems Biology in YeastGuang‐Zhong Wang — 2010
From Molecules to Organisms: Towards Multiscale Integrated Models of Biological SystemsChristophe Lavelle, Hugues Berry, Guillaume Beslon — 2008
Moment Closure Approximations in a Genetic Negative Feedback CircuitMohammad Soltani, Vargas, Cesar, Niraj Kumar — 2014
Dynamical modelling of feedback gene regulatory networksLan K. Nguyen — 2009
Evolutionary dynamics of metabolic adaptationMilan J. A. Hoek — 2008
Positive selection for unpreferred codon usage in eukaryotic genomesDaniel E. Neafsey, James E. Galagan — 2007
To be competent or not: an inquiry into the molecular basis of bacterial differentiationW. K. Smits — 2002
Simulation of microarray data with realistic characteristicsMatti Nykter, Tommi Aho, Miika Ahdesmäki — 2006
The utility of simple mathematical models in understanding gene regulatory dynamicsMichael C. Mackey, Moisés Santillán, Marta Tyran‐Kamińska — 2015
Role of Relaxation Time Scale in Noisy Signal TransductionAlok Kumar Maity, Pinaki Chaudhury, Suman Kumar Banik — 2014
Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradationC. Joel McManus, Zhe Cheng, Christine Vogel — 2015
Optimal feedback strength for noise suppression in autoregulatory gene networks.Abhyudai Singh, João P. Hespanha — 2009
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Noise Minimization in Eukaryotic Gene Expression

Summary

Keywords

References

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