A model for the statistical fluctuations of protein numbers in a microbial population.
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Summary
A model for the distribution of protein molecules between the cells in a microbial population during steady-state growth finds that this distribution is very broad, especially for small protein numbers; it is definitely not a Poisson distribution.
- Type
- article
- Published
- 1978-04-20
- Cited by
- 292
- References
- 10
- OpenAlex
- https://openalex.org/W2014409177
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29856863
Keywords
Poisson distribution, Repressor, Lac repressor, Cell division, Population
References
- Mutational inversion of control of the lactose operon of Escherichia coli.
- Distribution of suboptimally induces -D-galactosidase in Escherichia coli. The enzyme content of individual cells.
- The chromosome of Bacillus subtilis. I. Theory of marker frequency analysis.
- Chromosome replication and the division cycle of Escherichia coli B/r.
- Non-genetic individuality: chance in the single cell
- Mass action relations in vivo with application to the lac operon.
- The tight binding nature of the repressor-operon interaction.
- Transcription and translation initiation frequencies of the Escherichia coli lac operon.
- Induced synthesis of enzymes in bacteria analyzed at the cellular level.
- An Introduction to Probability Theory and Its Applications
- An introduction to probability theory and its applications
Cited by
- A comprehensive library of DNA-binding site matrices for 55 proteins applied to the complete Escherichia coli K-12 genome.
- Central dogma at the single-molecule level in living cells
- Robust Yet Fragile: Expression Noise, Protein Misfolding, and Gene Dosage in the Evolution of Genomes.
- Numerical solution of the Fokker–Planck approximation of the chemical master equation
- Reverse engineering of a metabolic, noise-exploiting control design
- Stochastic Modeling of Gene Regulatory Networks
- SYSTEMATIC INVESTIGATION OF QUORUM SENSING IN Escherichia coli
- Stochastic Gene Expression
- Problems of high dimension in molecular biology
- Analyse et modélisation de la stochasticité de l'expression génique dans des cellules eucaryotes. (Analysis and modeling of gene expression stochasticity in eukaryotic cells)
- Stochastic kinetics of the circular gene hypothesis: Feedback effects and protein fluctuations
- Yeast Genetic Networks
- Statistical mechanics of non-Markovian exclusion processes
- Towards a global and systemic understanding of protein production in prokaryotes. (Vers une compréhension globale et systémique de la production des protéines chez les procaryotes)
- Stochasticity and time delays in gene expression and evolutionary game theory
- Cell-to-cell variability of gene expression dynamics in inducible regulatory networks
- Transcriptional and epigenetic fluctuations in single cells
- A Stochastic Model of the Production of Multiple Proteins in Cells
- STOCHASTIC DYNAMICS OF GENE TRANSCRIPTION
- Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters.
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