Enhancer interaction networks as a means for singular olfactory receptor expression
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Summary
The role of the transcription factor Bptf is established as a facilitator of both enhancer interactions and OR transcription, suggesting that the rare coincidence of numerous enhancers over a stochastically chosen OR may account for the singularity and robustness in OR transcription.
- Type
- article
- Published
- 2014-10-23
- Cited by
- 200
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970956961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16996773
Keywords
Biology, Enhancer, Olfactory receptor, Expression (computer science), Cell biology
References
- Fitting a Mixture Model By Expectation Maximization To Discover Motifs In Biopolymer
- The accessible chromatin landscape of the human genome
- Humans can Discriminate more than one Trillion Olfactory Stimuli
- A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design
- Odorant receptors govern the formation of a precise topographic map.
- Functional analysis of limb enhancers in the developing fin
- Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment
- A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube
- The chromosomal distribution of mouse odorant receptor genes.
- Interchromosomal association and gene regulation in trans.
- Co-opting the unfolded protein response to elicit olfactory receptor feedback
- High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation.
- Exonic transcription factor binding directs codon choice and impacts protein evolution
- Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
- An expansive human regulatory lexicon encoded in transcription factor footprints
- Nuclear compartmentalization of odorant receptor genes
- CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice
- Transcription factors mediate long-range enhancer–promoter interactions
- High-resolution profiling of histone methylations in the human genome.
- Negative Feedback Regulation Ensures the One Receptor-One Olfactory Neuron Rule in Mouse
Cited by
- Soft x-ray tomography reveals gradual chromatin compaction and reorganization during neurogenesis in vivo
- Antisense lncRNA transcription mediates DNA demethylation to drive stochastic Protocadherin α promoter choice
- Disruption of nuclear architecture as a cause of COVID-19 induced anosmia
- TRIP through the chromatin: a high throughput exploration of enhancer regulatory landscapes.
- Developmental regulation of neural map formation in the mouse olfactory system
- Epigenetic events regulating monoallelic gene expression
- Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons
- Monoallelic Expression of Olfactory Receptors
- Gene regulation during development in the light of topologically associating domains
- Chemosensory Receptor Specificity and Regulation
- Regulatory Domains and Their Mechanisms.
- Adult stem cells and other cancer residents. Part I
- Olfactory sensory neurons transiently express multiple olfactory receptors during development
- An Overview of Genome Organization and How We Got There: from FISH to Hi-C
- Three-layer Regulation Leads to Monoallelic and Diverse Olfactory Receptor Expression
- Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS
- Pan-cancer analyses of the nuclear receptor superfamily
- Crowdsourcing: Spatial clustering of low-affinity binding sites amplifies in vivo transcription factor occupancy
- The Capacity to Act in Trans Varies Among Drosophila Enhancers
- CROWDSOURCING: A NOVEL GROUP-LEVEL MECHANISM STRUCTURES CHROMATIN AND FOSTERS GENE-COMPLEX ACTIVATION
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