Role of poly(ADP-ribose) formation in DNA repair
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Summary
The results indicate that unmodified polymerase molecules bind tightly to DNA strand breaks; auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes.
- Type
- article
- Published
- 1992-03-26
- Cited by
- 1,193
- References
- 23
- OpenAlex
- https://openalex.org/W1970184435
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4364270
Keywords
NAD+ kinase, Poly ADP ribose polymerase, Nicotinamide adenine dinucleotide, Polymerase, Biochemistry
References
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- In vitro transcription: whole-cell extract.
- Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.
- Poly(ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism.
- Poly(adenosine diphosphate ribose).
- Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.
- Stepwise assembly of chromatin during DNA replication in vitro.
- Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage.
- On the formation of a novel adenylic compound by enzymatic extracts of liver nuclei
- The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
- Presence of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase in the dinoflagellate Crypthecodinium cohnii.
- Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.
- The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase.
- Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.
- Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts.
- Poly(ADP-ribose) polymerase is a zinc metalloenzyme.
- (ADP-ribose)n participates in DNA excision repair
- Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity.
Cited by
- Changes of the proteasomal system during the aging process.
- PARP Expression Is Increased in Astrocytes but Decreased in Motor Neurons in the Spinal Cord of Sporadic ALS Patients
- Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks
- Macrophages in islet destruction in autoimmune diabetes mellitus.
- Long-term alcohol effects on hepatic phosphoglucomutase activities in relation to posttranslational modification of the protein.
- Human Malignant Glioma Therapy Using Anti-αVβ3 Integrin Agents
- Functional Competition between Poly(ADP-ribose) Polymerase and Its 24-kDa Apoptotic Fragment in DNA Repair and Transcription*
- DNA damage repair and genetic polymorphisms: assessment of individual sensitivity and repair capacity.
- Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation
- Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers.
- PARP1 gene expression is downregulated by knockdown of PARG gene
- Activation of Poly-ADP-ribosyl Synthase in Sepsis, Ischemia/Reperfusion, and Inflammation
- Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair
- Inhibition of nemo-like kinase increases taxol sensitivity in laryngeal cancer.
- Evidence and conjecture about mechanisms of cutaneous disease in photodermatology
- Small-molecule collection and high-throughput colorimetric assay to identify PARP1 inhibitors
- Research Progress on PARP14 as a Drug Target
- Molecular mechanisms of programmed cell death.
- Free radical stress-induced Parkinsonian Lewy-like aggregation prevented through polyphenolic phytochemical analog intervention: Implications for subcellular trafficking and neurodegenerative disorders
- Nitric Oxide as an Inflammatory Mediator in Insulin-Dependent Diabetes Mellitus
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