RNase H2-Initiated Ribonucleotide Excision Repair
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Summary
This work presents a complete biochemical reconstitution of the ribonucleotide excision repair (RER) pathway with enzymes purified from Saccharomyces cerevisiae and observed partial redundancy for several of the enzymes in this pathway.
- Type
- article
- Published
- 2012-08-02
- Cited by
- 329
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970184264
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12990277
Keywords
Biology, DNA polymerase, Ribonucleotide, Proliferating cell nuclear antigen, DNA ligase
References
- Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦
- Molecular mechanism of PCNA-dependent base excision repair.
- Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity.
- Ribonuclease H: the enzymes in eukaryotes
- Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases
- Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
- Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.
- RNase H2 of Saccharomyces cerevisiae is a complex of three proteins.
- The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
- Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen (*)
- Okazaki Fragment Maturation in Yeast
- Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ε
- Global analysis of protein expression in yeast
- Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε
- Choosing the right sugar: how polymerases select a nucleotide substrate.
- The Quaternary Structure of DNA Polymerase ε from Saccharomyces cerevisiae *
- Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage
- Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
- Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.
- Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage
Cited by
- Crystal structure of RNase H3–substrate complex reveals parallel evolution of RNA/DNA hybrid recognition
- ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe
- Mutagenic cost of ribonucleotides in bacterial DNA
- Functional Roles of Nucleases in DNA Metabolism and Genome Stability
- The Impact Of Down Syndrome And Folate Depletion On Genomic Stabilizing Pathways Of Lymphoblastoid Cells
- Measuring the elasticity of ribonucleotide(s)-containing DNA molecules using AFM.
- Type I interferonopathies—an expanding disease spectrum of immunodysregulation
- Role of RNase H1 in DNA repair: removal of single ribonucleotide misincorporated into DNA in collaboration with RNase H2
- Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae
- Recognition and repair of chemically heterogeneous structures at DNA ends
- DNA polymerase ε and its roles in genome stability
- Aicardi–Goutières syndrome: a model disease for systemic autoimmunity
- Formation and Repair of Mismatches Containing Ribonucleotides and Oxidized Bases at Repeated DNA Sequences*
- Structural basis for salt-dependent folding of ribonuclease H1 from halophilic archaeon Halobacterium sp. NRC-1.
- Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity*
- Ribonucleotide triggered DNA damage and RNA-DNA damage responses
- Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific
- Cost of rNTP/dNTP pool imbalance at the replication fork
- Rewriting the rules for end joining via enzymatic splicing of DNA 3′-PO4 and 5′-OH ends
- The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity
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