Immunohistochemical Localization of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Tissues1
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Summary
Activity and messenger ribonucleic acid studies indicate that type 1 11 βHSD (11βHSD1) is expressed in glucocorticoid target tissues such as liver, gonad, and cerebellum, where it regulates the exposure of cortisol to glucoc Corticoid receptors.
- Type
- article
- Published
- 1998-04-01
- Cited by
- 207
- References
- 45
- OpenAlex
- https://openalex.org/W1970175977
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10988572
Keywords
Immunohistochemistry, Dehydrogenase, Hydroxysteroid dehydrogenase, 11β-hydroxysteroid dehydrogenase type 1, Type (biology)
References
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- Effect of glucocorticosteroid treatment on glucocorticoid receptor expression in human adipocytes.
- 11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells.
- Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase
- Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.
- 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.
- Local Active Suppression by Suppressor Cells in the Decidua: A Review
- Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme.
- Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.
- 11 beta-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte.
Cited by
- Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.
- Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
- ROLE OF LOCAL 11beta-HYDROXYSTEROID DEHYDROGENASE TYPE 2 (HSD11B2) EXPRESSION IN DETERMINING THE PHENOTYPE OF ADRENAL ADENOMAS
- Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
- Role for prostaglandins in the regulation of type 1 11beta-hydroxysteroid dehydrogenase in human granulosa-lutein cells.
- Pistacia lentiscus Oleoresin: Virtual Screening and Identification of Masticadienonic and Isomasticadienonic Acids as Inhibitors of 11β-Hydroxysteroid Dehydrogenase 1
- Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system
- Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus.
- 11 beta-Hydroxysteroid dehydrogenase.
- Corticosteroid hormone action in the cardiovascular system
- Estrogen and Glucocorticoid Metabolism
- Structure-function analysis of 11β-hydroxysteroid dehydrogenase
- Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging.
- Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
- The effects of ovarian enzyme modulators on folliculogenesis and cyst development in the porcine ovary.
- The Dehydrogenase Hypothesis.
- 11beta-Hydroxysteroid Dehydrogenasen in der Cortison/Cortisol-Umwandlung
- Regulation and function of 11β-hydroxysteroid dehydrogenase (11β-HSD1) in pancreatic β-cells
- Enzymology and molecular biology of glucocorticoid metabolism in humans.
- The role of steroid hormones in skeletal muscle metabolism
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