Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.
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Summary
This work provides direct evidence that U-to-C RNA editing of an insect sodium channel transcript generates a sodium channel with a persistent current, and provides direct support for the hypothesis that posttranscriptional modification of a conventional transient sodium channel produces a persistent TTX-sensitive sodium channel.
- Type
- article
- Published
- 2004-08-10
- Cited by
- 68
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969991317
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10601702
Keywords
Sodium channel, Tetrodotoxin, RNA editing, Excitatory postsynaptic potential, Biology
References
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- Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization.
- Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function.
- Cloning of complementary DNAs encoding the amphibian bombesin-like peptides Phe8 and Leu8 phyllolitorin from Phyllomedusa sauvagei: potential role of U to C RNA editing in generating neuropeptide diversity.
- Inherited Brugada and Long QT-3 Syndrome Mutations of a Single Residue of the Cardiac Sodium Channel Confer Distinct Channel and Clinical Phenotypes*
- Implication of the C-Terminal Region of the α-Subunit of Voltage-gated Sodium Channels in Fast Inactivation
- Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons.
- A-to-I editing: new and old sites, functions and speculations.
Cited by
- Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Tracking a Feeding Adaptation from Populations Through Clades
- Etude des effets d'un composé soufré libéré par les Allium, le disulfure de diméthyle, sur les neurones d'insecte et sur l'activité électroencéphalographique de souris
- Caractérisation des sous-unités principales et auxiliaires des canaux sodium dépendant du potentiel exprimées dans le système nerveux central de l'insecte periplaneta americana
- Molecular Mechanisms of Pyrethroid Resistance in the Mosquito, Culex quinquefasciatus (Say)
- Voltage-Gated Sodium Channels as Insecticide Targets
- Ion channels in analgesia research.
- Molecular characterisation of a sodium channel gene and identification of a Phe1538 to Ile mutation in citrus red mite, Panonychus citri.
- Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels
- Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus
- Insect-selective spider toxins targeting voltage-gated sodium channels.
- A comparative study of voltage‐gated sodium channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species
- Molecular characterization of a new scorpion venom lipolysis activating peptide: Evidence for disulfide bridge‐mediated functional switch of peptides
- The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations associated with pyrethroid resistance in field-collected adult males.
- Pyrethroid resistance in mosquitoes
- Sodium current of neurosecretory cells in the eyestalk from the shrimp Penaeus japonicus
- Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides
- Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
- Insect sodium channels and insecticide resistance
- Molecular Biology of Insect Sodium Channels and Pyrethroid Resistance
- Sodium channel gene expression associated with pyrethroid resistant house flies and German cockroaches.
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