Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.

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Summary

This work provides direct evidence that U-to-C RNA editing of an insect sodium channel transcript generates a sodium channel with a persistent current, and provides direct support for the hypothesis that posttranscriptional modification of a conventional transient sodium channel produces a persistent TTX-sensitive sodium channel.

Type
article
Published
2004-08-10
Cited by
68
References
63
Access
Open access

Keywords

Sodium channel, Tetrodotoxin, RNA editing, Excitatory postsynaptic potential, Biology

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