From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
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Summary
Together, these studies showed that the mechanisms of sodium channel function and regulation, purified sodium channel protein contained the essential and gives a perspective for future research on the ex-elements for ion conduction and voltage-dependent panding family of Sodium channel proteins.
- Type
- review
- Published
- 2000-04-01
- Cited by
- 2,121
- References
- 113
- Access
- Open access
- OpenAlex
- https://openalex.org/W1983187084
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17928749
Keywords
Neuroscience, Ionic bonding, Biophysics, Psychology, Chemistry
References
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- Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
- Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons.
- The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits.
- Reconstitution of neurotoxin-stimulated sodium transport by the voltage-sensitive sodium channel purified from rat brain.
- Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy
- Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes.
- Radicals r'aging
- Growth Factor Receptor Tyrosine Kinases Acutely Regulate Neuronal Sodium Channels through the Src Signaling Pathway
- Voltage-Dependent Neuromodulation of Na+ Channels by D1-Like Dopamine Receptors in Rat Hippocampal Neurons
- Identification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases.
- Cyclic AMP-dependent phosphorylation of the alpha subunit of the sodium channel in synaptic nerve ending particles.
- Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes
- Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel
- Molecular Dynamics of the Sodium Channel Pore Vary with Gating: Interactions between P-Segment Motions and Inactivation
- Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B
Cited by
- Cardiac functions of voltage-gated Ca(2+) channels: role of the pharmacoresistant type (E-/R-Type) in cardiac modulation and putative implication in sudden unexpected death in epilepsy (SUDEP).
- Molecular mechanism of knockdown resistance to pyrethroid insecticides
- Role of Amino Acid Residues in Transmembrane Segments IS6 and IIS6 of the Na+ Channel α Subunit in Voltage-dependent Gating and Drug Block*
- Differential effects of bupivacaine enantiomers, ropivacaine and lidocaine on up-regulation of cell surface voltage-dependent sodium channels in adrenal chromaffin cells.
- A δ-Conotoxin from Conus ermineus Venom Inhibits Inactivation in Vertebrate Neuronal Na+ Channels but Not in Skeletal and Cardiac Muscles*
- Bacterial ion channels.
- A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels.
- Mechanisms of valence selectivity in biological ion channels
- The role of sodium channels in chronic inflammatory and neuropathic pain.
- Effects of BmKNJX11, A Bioactive Polypeptide Purified from Buthus martensi Karsch, on Sodium Channels in Rat Dorsal Root Ganglion Neurons
- Mechanistic insights on spider neurotoxins.
- Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
- Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
- Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels*
- Voltage‐gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin‐induced peripheral neurotoxicity: Results from a prospective multicenter study
- Functional Expression of Rat Nav1.6 Voltage-Gated Sodium Channels in HEK293 Cells: Modulation by the Auxiliary β1 Subunit
- Local anaesthetics: 10 essentials
- Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ
- Voltage-gated sodium channels.
- Action potential propagation: ion current or intramembrane electric field?
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