Up on the tightrope: natural killer cell activation and inhibition
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Summary
Recent advances in the understanding of the structural properties and signaling pathways of the inhibitory and activating NK cell receptors are highlighted, with a particular focus on the ITAM-dependent activating receptors, the NKG2D-DAP10 receptor complexes and the CD244 receptor system.
- Type
- review
- Published
- 2008-05-01
- Cited by
- 1,681
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969950463
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5202485
Keywords
NKG2D, Receptor, Cell biology, Biology, Lymphokine-activated killer cell
References
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- UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells
- Engagement of NKG2D by Cognate Ligand or Antibody Alone Is Insufficient to Mediate Costimulation of Human and Mouse CD8+ T Cells1
- The Adaptor Protein 3BP2 Binds Human CD244 and Links this Receptor to Vav Signaling, ERK Activation, and NK Cell Killing1
- A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells.
- Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets1
- Regulation of Ly49D/DAP12 Signal Transduction by Src-Family Kinases and CD4512
- Cutting Edge: Activation of NK Cell-Mediated Cytotoxicity by a SAP-Independent Receptor of the CD2 Family1
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- Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells.
- Analysis of the molecular mechanism involved in 2B4‐mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells
- Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells
- Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.
Cited by
- Development and Function of CD94-Deficient Natural Killer Cells
- Natural Killer Cell Responses to Viral Infection
- IQGAP1 involvement in MTOC and granule polarization in NK‐cell cytotoxicity
- HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway
- A modified FCCS procedure applied to Ly49A-MHC class I cis-interaction studies in cell membranes.
- Phenotypic and functional studies of NK cells in neonates and during early childhood
- Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP
- Ozone exposed epithelial cells modify cocultured natural killer cells.
- Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1
- EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells
- Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection
- Human NK cells and NK receptors.
- Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients
- Metabolic Regulation of Natural Killer Cell IFN-γ Production
- Avelumab, an IgG1 anti-PD-L1 Immune Checkpoint Inhibitor, Triggers NK Cell-Mediated Cytotoxicity and Cytokine Production Against Triple Negative Breast Cancer Cells
- CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques
- Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions
- Extracellular proliferating cell nuclear antigen as a marker and therapeutic target for cancer stem cells
- Impacto de los inhibidores de Deacetilasas de Histonas (iHDAC) sobre la funcionalidad de células NK
- The molecular determinants of tumor cell sensitivity and resistance to antibody-dependent cellular cytotoxicity (ADCC)
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