Turning tumor cells in situ into T-helper cell-stimulating, MHC class II tumor epitope-presenters: immuno-curing and immuno-consolidation.
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Summary
This work has developed analogous human gene vectors that are suitable for most patients and cancers, because they are monomorphic and active in all HLA-DR alleles and suppress expression of the Ii protein, that normally blocks the antigenic peptide binding site of MHC class II molecules during synthesis in the endoplasmic reticulum.
- Type
- review
- Published
- 2004-05-01
- Cited by
- 26
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969888145
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6893650
Keywords
Medicine, Immunology, Epitope, Major histocompatibility complex, MHC class I
References
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- Genetic control of MHC class II expression.
- Cancer immunotherapy by antisense suppression of Ii protein in MHC-class-II-positive tumor cells
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- Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors.
- Induction of MHC class I expression by the MHC class II transactivator CIITA.
- Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer
- Mixed growth hormone cell- prolactin cell pituitary adenoma with acromegaly: α-subunit most growth hormone cells
Cited by
- Low expression of HLA‐DRA, HLA‐DPA1, and HLA‐DPB1 is associated with poor prognosis in pediatric adrenocortical tumors (ACT)
- Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
- CD4+ T cells in antitumor immunity: utility of an Ii-Key HER2/neu hybrid peptide vaccine (AE37)
- Cysteine cathepsins: regulators of antitumour immune response
- Curative Antitumor Immune Response Is Optimal with Tumor Irradiation Followed by Genetic Induction of Major Histocompatibility Complex Class I and Class II Molecules and Suppression of Ii Protein
- Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A
- Antitumour activity mediated by CD4+ cytotoxic T lymphocytes against MHC class II‐negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin‐12
- Invariant chain+ N2a neuroblastoma cells stably expressing the class II MHC transactivator CIITA fail to stimulate anti-tumor immunity.
- HLA class II antigen presentation by prostate cancer cells
- HLA Class II Antigen Presentation in Prostate Cancer Cells: A Novel Approach to Prostate Tumor Immunotherapy
- Genome-Wide Transcription Responses to Synchrotron Microbeam Radiotherapy
- MHC class II molecules and tumour immunotherapy
- Radiation Improves Intratumoral Gene Therapy for Induction of Cancer Vaccine in Murine Prostate Carcinoma
- Forcing tumor cells to present their own tumor antigens to the immune system: a necessary design for an efficient tumor immunotherapy.
- Ovarian cancer and the immune system - The role of targeted therapies.
- Tumor cell transformation using antisense oligonucleotide.
- Epigenetic therapy for the treatment of epithelial ovarian cancer: A clinical review
- The anti-tumor effects of entinostat in ovarian cancer require adaptive immunity
- The small molecule antibody mimic SH7139 targets a family of HLA-DRs expressed by B-cell lymphomas and other solid cancers
- Comprehensive Analysis of Immune-Related Metabolic Genes in Lung Adenocarcinoma
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