Alcohol reward, dopamine depletion, and GDNF

Summary

In 1985, Dackis and Gold suggested that cocaine addiction stems from the depletion of synaptic dopamine in the mesolimbic dopamine reward system, leading to a dysphoric withdrawal state that drives cocaine seeking to restore dopamine to normal, drug-naive levels.

Keywords

Dopamine, Addiction, Neuroscience, Reward system, Psychology

References

Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.Jane Stewart — 2000
Role of BDNF and GDNF in drug reward and relapse: a reviewUdi E. Ghitza, Haifeng Zhai, Ping Wu — 2009
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats.Zvani L. Rossetti, Yousef Hmaidan, G L Gessa — 1992
New concepts in cocaine addiction: the dopamine depletion hypothesis.Charles A. Dackis, Mark S. Gold — 1985
Regional differences within the rat ventral tegmental area for muscimol self-infusions.Satoshi Ikemoto, James M. Murphy, William J. McBride — 1998
Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence.George F. Koob, Luis Stinus, Michel Le Moal — 1989
GDNF — A potential target to treat addictionSébastien Carnicella, Dorit Ron — 2008
Glial Cell Line-Derived Neurotrophic Factor Reverses Alcohol-Induced Allostasis of the Mesolimbic Dopaminergic System: Implications for Alcohol Reward and SeekingSegev Barak, Sébastien Carnicella, Quinn V. Yowell — 2011
Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawalYavin Shaham, Heshmat Rajabi, Jane Stewart — 1996
GDNF is an Endogenous Negative Regulator of Ethanol-Mediated Reward and of Ethanol Consumption After a Period of AbstinenceSébastien Carnicella, Somayeh Ahmadiantehrani, Patricia H. Janak — 2009
Deprivation State Switches the Neurobiological Substrates Mediating Opiate Reward in the Ventral Tegmental AreaKarim Nader, Derek van der Kooy — 1997

Cited by

The dopamine transporter gene SLC6A3: multidisease risksMaarten E. A. Reith, Sandhya Kortagere, Corinde E. Wiers — 2021
Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s DiseaseTadahiro Numakawa, Ryutaro Kajihara — 2023
Ethanol: Neurotoxicity and Brain DisordersL. M. Fernandes, E. Andrade, M. Monteiro — 2017

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