A Map of the Mouse Cyp3a Locus
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Summary
The mouse Cyp3a locus on chromosome 5 was analyzed by the use of bacterial artificial chromosomes providing evidence for duplication events within the locus and covers a larger chromosomal region and appears to be considerably more complex.
- Type
- article
- Published
- 2003-06-01
- Cited by
- 10
- References
- 14
- OpenAlex
- https://openalex.org/W1787868867
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21317627
Keywords
Locus (genetics), Biology, Genetics, Gene duplication, CYP3A
References
- CYP3A genetics in drug metabolism
- A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.
- Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.
- Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.
- The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.
- Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6β‐hydroxylase
- A comprehensive set of sequence analysis programs for the VAX
- A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
- Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
- Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).
- Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
- Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene.
- Molecular phylogeny of Rodentia, Lagomorpha, Primates, Artiodactyla, and Carnivora and molecular clocks.
- Cytochrome P-450 3A4: regulation and role in drug metabolism.
Cited by
- Molecular Diversity and Population Structure at the CYP3A5 gene in Africa
- A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.
- Synergism of Glucocorticoid Hormone with Growth Hormone for Female-Specific Mouse Cyp3a44 Gene Expression
- Origins of P450 diversity
- Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course
- Lessons from the CYP3A4 promoter.
- female-specific mouse Cyp3a44 gene expression
- Physiologic effects of cytochrome P450 3A activity
- RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice
- Lactobacillus plantarum alleviate aflatoxins (B1 and M1) induced disturbances in the intestinal genes expression and DNA fragmentation in mice
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