O2 regulates stem cells through Wnt/β-catenin signalling
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Summary
It is shown that hypoxia inducible factor-1 α (HIF-1α), a principal mediator of hypoxic adaptations, modulates Wnt/β-catenin signalling in hypoxic embryonic stem (ES) cells by enhancing β- catenin activation and expression of the downstream effectors LEF-1 and TCF- 1.
- Type
- article
- Published
- 2010-09-19
- Cited by
- 448
- References
- 35
- OpenAlex
- https://openalex.org/W1968461724
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10276262
Keywords
Cell biology, Wnt signaling pathway, Stem cell, Neural stem cell, Biology
References
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- Nuclear localization of β-catenin by interaction with transcription factor LEF-1
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- Expansion of human SCID-repopulating cells under hypoxic conditions.
- Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
- Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
- Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions
- Regulation of human placental development by oxygen tension.
- Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.
- Wnt signalling regulates adult hippocampal neurogenesis
- XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
- Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
- Hypoxia requires notch signaling to maintain the undifferentiated cell state.
- HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
- A Specialized Vascular Niche for Adult Neural Stem Cells
- HIF‐1α is required for solid tumor formation and embryonic vascularization
- The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.
Cited by
- Signaling Roadmap Modulating Naive and Primed Pluripotency
- Hypoxia-Mediated Regulation of Stem Cell Fate
- Oxygen‐induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization
- Nuclear Localization of the Mitochondrial Factor HIGD1A during Metabolic Stress
- Regulation of cell proliferation by hypoxia-inducible factors.
- Hematopoietic Stem Cell Threshold Sensing Controls Regulatory Pathways Facilitating Clinically Relevant Ex Vivo Expansion for Stem Cell Transplantation
- Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features
- The Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and Immunology
- Evaluating and Optimizing a Protocol for Mesodermal Differentiation of Pluripotent Stem Cells towards Cardiomyocytes and Adipocytes
- Studies on regulation of versican gene expression by hypoxia in primary human macrophages
- The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis
- Deferoxamine Preconditioning of Neural-Like Cells Derived from Human Wharton’s Jelly Mesenchymal Stem Cells as a Strategy to Promote Their Tolerance and Therapeutic Potential: An In Vitro Study
- Embryonic NANOG Activity Defines Colorectal Cancer Stem Cells and Modulates through AP1‐ and TCF‐dependent Mechanisms
- Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice
- Ex vivo expansion of cord blood haematopoietic stem/progenitor cells under physiological oxygen tensions: clear‐cut effects on cell proliferation, differentiation and metabolism
- Effects of rat cytomegalovirus on the nervous system of the early rat embryo
- Hypoxic regulation of MYC and epidermal barrier development
- To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma
- INSIGHTS INTO HEPATIC ALPHA- FETOPROTEIN GENE REGULATION DURING LIVER DEVELOPMENT AND DISEASE
- Potential for pharmacological manipulation of human embryonic stem cells
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