Binding of heparan sulfate glycosaminoglycan to β‐amyloid peptide: inhibition by potentially therapeutic polysulfated compounds
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Summary
It is demonstrated that heparin sulfate glycosaminoglycan and proteoglycan both bind to the beta-amyloid peptide involved in Alzheimer's disease.
- Type
- article
- Published
- 1994-06-01
- Cited by
- 71
- References
- 0
- OpenAlex
- https://openalex.org/W1967873229
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27638062
Keywords
Fibrillogenesis, Heparan sulfate, Glycosaminoglycan, Heparin, Proteoglycan
References
No references recorded for this paper.
Cited by
- Glycosaminoglycans and neuroprotection.
- Heparin - A Century of Progress
- Inhibition of Amyloidosis Using Low-Molecular-Weight Heparins
- Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity
- Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth.
- Amiloidosis secundaria en la artritis reumatoide
- Low molecular weight glycosaminoglycan C3 attenuates AF64A-stimulated, low-affinity nerve growth factor receptor-immunoreactive axonal varicosities in the rat septum.
- Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons.
- Interleukin-1 and nerve growth factor induce hypersecretion and hypersulfation of neuroblastoma proteoglycans which bind beta-amyloid.
- Low molecular weight glycosaminoglycan blockade of β-amyloid induced neuropathology
- Neuroprotective Properties of Glycosaminoglycans: Potential Treatment for Neurodegenerative Disorders
- Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion
- Small molecule inhibitors of Aβ‐aggregation and neurotoxicity
- The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.
- A beta amyloidogenesis: unique, or variation on a systemic theme?
- Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease
- The chemical neurobiology of carbohydrates.
- Sand in the sheets
- Pathogenic Factors in Vascular Dementia and Alzheimer’s Disease
- The Heparin/Heparan Sulfate-binding Site on Apo-serum Amyloid A
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