Inhibition of IL-6 family cytokines by SOCS3
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Summary
A model in which each of gp130, JAK and SOCS3 are directly bound to the other two, allowing SOCS3 to inhibit IL-6 signalling with high potency and specificity is proposed.
- Type
- review
- Published
- 2014-01-10
- Cited by
- 213
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967551645
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28069982
Keywords
Tyrosine kinase 2, SOCS3, Glycoprotein 130, Janus kinase, Suppressor of cytokine signalling
References
- A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.
- CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.
- A new protein containing an SH2 domain that inhibits JAK kinases
- Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain
- A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
- A family of cytokine-inducible inhibitors of signalling
- Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3 1
- The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function
- Soluble receptors for cytokines and growth factors: generation and biological function.
- Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
- The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype‐specific mechanisms
- SOCS3 regulates the plasticity of gp130 signaling
- Suppression of Cytokine Signalling by SOCS3: Characterisation of the mode of inhibition and the basis of its specificity
- Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
- CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2*
- The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities*
- Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone*
- Tyrosine Phosphorylation Disrupts Elongin Interaction and Accelerates SOCS3 Degradation*
- The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
- Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
Cited by
- Macroporous resin purification and characterization of flavonoids from Platycladus orientalis (L.) Franco and their effects on macrophage inflammatory response.
- Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
- IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy.
- Characterization of the roles of suppressor of cytokine signaling‐3 in prostate cancer development and progression
- Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
- Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer.
- Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms
- The role of wogonin in controlling SOCS3 expression in neuronal cells.
- DNA methylation analysis of SOCS1, SOCS3, and LINE-1 in microdissected gingival tissue
- The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition.
- Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome.
- JAK2 activation by growth hormone and other cytokines
- IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance
- The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity.
- IL-6 promotes an increase in human mast cell number and reactivity through suppression of SOCS3
- Transcriptional regulation of the anti-inflammatory protein tristetraprolin (TTP)
- An altered peripheral IL6 response in major depressive disorder
- Endocytosis of pro-inflammatory cytokine receptors and its relevance for signal transduction
- Hypoxic Conditioned Medium From Human Adipose‐Derived Stem Cells Promotes Mouse Liver Regeneration Through JAK/STAT3 Signaling
- Spring viraemia of carp virus: recent advances.
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