α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment
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Summary
It is demonstrated that α2-adrenoceptors, expressed by progenitor cells, decrease adult hippocampal neurogenesis, while their blockade speeds up antidepressant action, highlighting their importance as targets for faster acting antidepressants.
- Type
- article
- Published
- 2010-01-20
- Cited by
- 93
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967437665
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16457164
Keywords
Neurogenesis, Yohimbine, Hippocampal formation, Endocrinology, Imipramine
References
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- Brain α2‐adrenoceptors in monoamine‐depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA
- Molecular identification and coexpression of galanin and GalR-1 galanin receptor in the human ocular ciliary epithelium: differential modulation of their expression by the activation of alpha2- and beta2-adrenergic receptors in cultured ciliary epithelial cells.
- Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice.
- A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine.
- Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
- A New Role for FGF2 as an Endogenous Inhibitor of Anxiety
- Up‐Regulation of Immunolabeled α2A‐Adrenoceptors, Gi Coupling Proteins, and Regulatory Receptor Kinases in the Prefrontal Cortex of Depressed Suicides
- Piribedil Enhances Frontocortical and Hippocampal Release of Acetylcholine in Freely Moving Rats by Blockade of α2A-Adrenoceptors: A Dialysis Comparison to Talipexole and Quinelorane in the Absence of Acetylcholinesterase Inhibitors
- Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals
- Does mirtazapine have a more rapid onset than SSRIs?
- Adult hippocampal neurogenesis in depression
- The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors.
- Antidepressant drug treatment induces Arc gene expression in the rat brain.
- Electroconvulsive Therapy and the Alpha-2 Noradrenergic Receptor: Implications of Treatment Schedule Effects
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Cited by
- Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients.
- GPCRs in Stem Cell Function
- Molecular and cellular mechanisms of antidepressant action.
- Novel insights into depression and antidepressants: a synergy between synaptogenesis and neurogenesis?
- Alpha2‐adrenergic receptor activation regulates cortical interneuron migration
- Neurotoxicity of prenatal alcohol exposure on medullary pre-Bötzinger complex neurons in neonatal rats
- Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells.
- Antidepressant-like properties of three new α2-adrenoceptor antagonists.
- Is acupuncture “stimulation” a misnomer? A case for using the term “blockade”
- S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α2-Adrenoceptor Antagonist and Potential Antidepressant: II. A Behavioral, Neurochemical, and Electrophysiological Characterization
- Implication of NGF and endocannabinoid signaling in the mechanism of action of sesamol: a multi-target natural compound with therapeutic potential
- Antidepressants for neuro-regeneration: from depression to Alzheimer’s disease
- In vivo potentiation of reboxetine and citalopram effect on extracellular noradrenaline in rat brain by α2-adrenoceptor antagonism.
- Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis
- Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity
- Pharmacogenetics of antidepressant drugs: An update after almost 20 years of research
- Participation of brainstem monoaminergic nuclei in behavioral depression
- Choice of saccade endpoint under risk.
- Affective disorders: A faster way to happiness
- Hypothalamic Subependymal Niche: A Novel Site of the Adult Neurogenesis
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