Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients.
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Summary
Re-examine the status of platelet membrane GRK2 protein in patients with MDD, along with GRK3 (a close kinase homolog) and GRK5 (a kinase with different properties), before and after treatment with serotonin-selective reuptake inhibitor (SSRI) or serotonin noradrenaline reuptakes inhibitor (SNRI) antidepressants indicated that plateletGRK2 and p-Ser670 GRK1 were reduced in unmedicated MD
- Type
- article
- Published
- 2010-10-01
- Cited by
- 36
- References
- 53
- OpenAlex
- https://openalex.org/W20493668
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22166946
Keywords
Political science
References
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Cited by
- Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics
- G protein–coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor–promoted centrosomal separation
- FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.
- The genetics of selective serotonin reuptake inhibitors.
- Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*
- Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: Effect of antidepressant treatment
- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
- Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder
- Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia
- Quantification of endocannabinoids in postmortem brain of schizophrenic subjects.
- Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents.
- α2 adrenergic receptor dysregulation in depressive disorders: implications for the neurobiology of depression and antidepressant therapy
- G Protein-coupled Receptor Kinase 5 Phosphorylates Nucleophosmin and Regulates Cell Sensitivity to Polo-like Kinase 1 Inhibition*
- Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs
- Neuroinflammation and Comorbidity of Pain and Depression
- Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia
- G Protein Signaling in Autistic Endophenotypes
- Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.
- Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression.
- Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects
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