Perspective: Postmenopausal Osteoporosis as a Failure of Bone's Adaptation to Functional Loading: A Hypothesis *
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Summary
Research to prevent or treat osteoporosis could be directed usefully to understanding how osteoblasts, lining cells, and osteocytes respond to mechanically derived information and how these responses are converted into stimuli controlling structurally appropriate modeling and remodeling.
- Type
- review
- Published
- 2001-11-01
- Cited by
- 255
- References
- 136
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967010727
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35823899
Keywords
Osteoporosis, Postmenopausal osteoporosis, Adaptation (eye), Perspective (graphical), Medicine
References
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- Estrogen therapy and variable‐resistance weight training increase bone mineral in surgically menopausal women
- Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation.
- Effect of Starting Age of Physical Activity on Bone Mass in the Dominant Arm of Tennis and Squash Players
- Early Responses to Dynamic Strain Change and Prostaglandins in Bone‐Derived Cells in Culture
- Additive effects of weight‐bearing exercise and estrogen on bone mineral density in older women
- Cellular responses to mechanical loading in vitro
- The site-specific effects of long-term unilateral activity on bone mineral density and content.
Cited by
- Emerging views about “osteoporosis”, bone health, strength, fragility, and their determinants
- Long-term potentiation in bone – a role for glutamate in strain-induced cellular memory?
- The bone-muscle ratio of fetal lambs is affected more by maternal nutrition during pregnancy than by maternal size.
- A critical review of exercise training effects on bone mineral density (BMD) in early postmenopausal women : article review
- Spanish Missionization and Maya Social Structure: Skeletal Evidence for Labor Distribution at Tipu, Belize
- On the pathogenesis of osteogenesis imperfecta: some insights of the Utah paradigm of skeletal physiology.
- The benefit of combining non-mechanical agents with mechanical loading: a perspective based on the Utah Paradigm of Skeletal Physiology.
- The development and anatomy of the sacrum in relation to the ilium and the sacroiliac joint
- Exercise loading and bone structure
- A qualitative and quantitative investigation of structural morphology in the neonatal ilium
- Relationship between lower limb neuromuscular performance and bone strength in postmenopausal women with mild knee osteoarthritis.
- Birth is but our death begun: a bioarchaeological assessment of skeletal emaciation in immature human skeletons in the context of environmental, social, and subsistence transition.
- Bone Geometry as a Predictor of Tissue Fragility and Stress Fracture Risk
- Exploring bone dynamics using in-vivo micro-CT imaging
- Long bone bilateral asymmetry in the nineteenth-century Stirrup Court Cemetery collection from London, Ontario
- Beeinflussung der Knochenparameter und der Knochendefektheilung des osteoporotischen Knochens am Modell der orchidektomierten Ratte durch Vibrationstherapie in Kombination mit Dihydrotestosteron und Östradiol
- Strain-related control of bone (re)modeling: objectives, mechanisms and failures.
- Gender comparison of factors associated with age-related differences in bone mineral density
- Cancellous Bone Adaptation To Non-Invasive Mechanical Loading In The Murine Tibia
- The structural mechanics and evolution of aquaflying birds
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