Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation.
Explore this paper's citation graph
Summary
A rapid surge in bone resorption was reflected in a significant increase in the number of osteoclasts per mm bone surface at 30 and 72 h and in the osteoclast surface at 72 h but not at later times, and a sustained decrease in bone mineral apposition rate and bone formation rate throughout the 42-day immobilization period suggesting osteoblastic hypofunction (reduced activity).
- Type
- article
- Published
- 1989-01-01
- Cited by
- 279
- References
- 23
- OpenAlex
- https://openalex.org/W1973830769
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25084664
Keywords
Osteopenia, Tenotomy, Medicine, Bone resorption, Femur
References
- Effects of a 120 day period of bed-rest on bone mass and bone cell activities in man: attempts at countermeasure.
- Effects of spaceflight on trabecular bone in rats.
- Skeletal response to simulated weightlessness: a comparison of suspension techniques.
- Isotopic evidence for resorption of soft tissues and bone in immobilized dogs.
- Effects of recumbency and space flight on bone density.
- Effect of long-term immobilisation on the pattern of bone loss in older dogs.
- Inhibition of bone formation during space flight.
- Evidence of sequential remodeling in rat trabecular bone: Morphology, dynamic histomorphometry, and changes during skeletal maturation
- Inhibition of cortical and trabecular bone formation in the long bones of immobilized monkeys.
- Effect of long-term nontraumatic immobilization on metaphyseal spongiosa in young adult and old beagle dogs.
- Immobilization-associated osteoporosis in primates.
- Parathyroid and thyroid hormones in the development of immobilization osteoporosis.
- The effects of immobilization on bone histomorphometry in rats
- Indomethacin inhibition of tenotomy‐induced bone resorption in rats
- LONGITUDINAL BONE GROWTH AFTER SCIATIC DENERVATION IN RATS
- Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
- The effects of ovariectomy and 17β‐estradiol on cortical bone histomorphometry in growing rats
- Bone and muscle atrophy with suspension of the rat.
- Regulation of bone formation by applied dynamic loads.
- Early metabolic responses of bone to immobilization.
Cited by
- Effect of clodronate on fracture healing in denervated rats.
- Local and systemic factors in the pathogenesis of osteoporosis.
- Biomaterials and biomechanics of oral and maxillofacial implants: current status and future developments.
- An evaluation of bone loss after total hip arthroplasty for femoral head necrosis after femoral neck fracture: a quantitative CT study in 16 patients.
- Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not
- The effects of hibernation on bone in yellow-bellied marmots
- Controlled In Vivo Mechanical Stimulation of Bone Repair Constructs
- Simulations of bone remodeling at the cellular scale
- Close to the bone : investigations into bone tissue mineralisation and mechanobiology of osteoporosis
- Vitamins, fatty acids, physical activity and peak bone mass
- Influencia del plasma rico en plaquetas en la regeneración ósea: estudio densitométrico y morfométrico en calota de conejas osteoporóticas
- The effects of chronic unloading and gap formation on tendon-to-bone healing in a rat model of massive rotator cuff tears
- Effects of Sciatic Neurectomy on Arthritis and Bone Loss in Rats with Collagen-Induced Arthritis
- Comparative effects of orchidectomy and sciatic neurectomy on cortical and cancellous bone in young growing rats
- The physiology of habitual bone strains
- Disuse osteopenia is accompanied by downregulation of gene expression for bone proteins in growing rats.
- Alendronate does not prevent long bone fragility in an inactive rat model
- Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae.
- EVALUATION OF THE EFFECT OF TAMOXIFEN CITRATE ON MODEL OF OSTEOPOROSIS IN DOG: BIOMECHANICAL AND HISTOPATHOLOGICAL STUDIES
- Bone mass homeostasis and bisphosphonate action.
Related papers
- Comparison of bone loss during normal lactation with estrogen deficiency osteopenia and immobilization osteopenia in the rat
- Time course of vertebral osteopenia in ovariectomized rats.
- Appearance of osteoclasts by injections of lipopolysaccharides in rat periodontal tissue.
- Macrophage Colony Stimulating Factor Increases Bone Resorption in Dispersed Osteoclast Cultures by Increasing Osteoclast Size
- The effects of sodium fluoride on the resorptive activity of isolated osteoclasts
- Physical/Chemical Properties and Resorption Behavior of a Newly Developed Ca/P/S-Based Bone Substitute Material
- Indomethacin inhibition of tenotomy‐induced bone resorption in rats
- Biomechanical Effects of Simulated Resorption Cavities in Cancellous Bone Across a Wide Range of Bone Volume Fraction