Differential expression of two distinct T-cell receptors during thymocyte development
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Summary
It is shown here that the first T3-associated TCR to be expressed in the developing thymus is a disulphide-linked heterodimer composed of a γ-chain of relative molecular mass 35,000 (Mr 35K) and a 45K partner (termed TCR δ).
- Type
- article
- Published
- 1987-03-01
- Cited by
- 346
- References
- 14
- OpenAlex
- https://openalex.org/W1966949361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4274967
Keywords
Thymocyte, Receptor, Cell biology, Differential (mechanical device), Biology
References
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- Diversity, rearrangement, and expression of murine T cell gamma genes.
- Structure, organization, and somatic rearrangement of T cell gamma genes.
- Characterization of murine thymocytes with CDS-associated T-cell receptor structures
- Expression of T-cell antigen receptor genes during fetal development in the thymus
- Synchronized rearrangement of T-cell gamma and beta chain genes in fetal thymocyte development.
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences
- Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes.
- A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes
- Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F.
- Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
- Identification of a putative second T-cell receptor
- Developmental regulation of T-cell receptor gene expression
- Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5
Cited by
- Molecular analysis of T cell receptor gamma gene expression in allo‐activated splenic T cells of adult mice
- Contrasuppression in the mucosal immune system
- Intraepithelial lymphocytes and the immune system.
- Development and selection of T cells: facts and puzzles.
- Monoclonal antibodies that identify the CD3 molecules expressed specifically at the surface of porcine γδ‐T cells
- Normal and aberrant T-cell receptor protein expression in T-cell acute lymphoblastic leukemia.
- The development of functionally responsive T cells.
- Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?
- γδ T Lymphocytes in Mice and Man: A Review
- Diversity of the immunoglobulin gene superfamily.
- Understanding the molecular basis of γδ T cell receptor ligand recognition in cellular stress surveillance
- Factors mediating successful oral vaccination with lipid-encapsulated Mycobacterium bovis BCG
- Maternal helminth infections.
- ad1 and y8 T cells can share a late common precursor
- Compartmentalization of the peripheral immune system.
- Role of NK cells in DC-based immunotherapy of melanoma
- Selection of V delta+ T cell receptors of intestinal intraepithelial lymphocytes is dependent on class II histocompatibility antigen expression.
- The unfolding story of T cell receptor γ
- T cell receptor and function cosegregate in gamma-delta T cell subsets.
- Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes
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