Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway.
Explore this paper's citation graph
Summary
Results show that running exercise protects DA neurons against inflammation-induced insults, and the neuroprotective effects of Ex are not due to the modulation of inflammation status, but rather to the activation of the BDNF-TrkB signaling pathway.
- Type
- article
- Published
- 2011-01-01
- Cited by
- 216
- References
- 80
- OpenAlex
- https://openalex.org/W20851176
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205861347
Keywords
Computer science, Geography
References
- Treadmill training for the treatment of gait disturbances in people with Parkinson’s disease: a mini-review
- Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos
- Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor.
- The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma.
- Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
- Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
- Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients.
- Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation
- Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons.
- Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
- Effects of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon
- BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
- Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation
- K‐252 Compounds: Modulators of Neurotrophin Signal Transduction
- Motor training effects on recovery of function after striatal lesions and striatal grafts.
- Effects of Enhanced Striatal Dopamine Turnover In Vivo on Glutathione Oxidation
- Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.
- Glucocorticoid signaling and exercise-induced downregulation of the mineralocorticoid receptor in the induction of adult mouse dentate neurogenesis by treadmill running.
- Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain.
- The response of human and rat fetal ventral mesencephalon in culture to the brain-derived neurotrophic factor treatment.
Cited by
- Does vigorous exercise have a neuroprotective effect in Parkinson disease?
- Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel
- Oxidation and reactivity of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism
- Effect of six weeks of endurance exercise and following detraining on serum brain derived neurotrophic factor and memory performance in middle aged males with metabolic syndrome.
- NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS
- Aging and Exercise Affect Hippocampal Neurogenesis via Different Mechanisms
- Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease.
- An examination of the acute and chronic effects of exercise on cognitive function in older adults
- Early postinjury exercise reverses memory deficits and retards the progression of closed‐head injury in mice
- Peripheral inflammation remotely triggers global gene expression changes in the brain
- The impact of high intensity physical training on motor and non-motor symptoms in patients with Parkinson's disease (PIP): A preliminary study
- Effect of exercise on mouse liver and brain bioenergetic infrastructures
- Exercise-induced neuroplasticity in human Parkinson's disease: What is the evidence telling us?
- Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review
- Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex
- 7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress
- Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23.
- Preconditioning Provides Neuroprotection in Models of CNS Disease: Paradigms and Clinical Significance
- The Simon task and aging: does acute moderate exercise influence cognitive control?
- Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review
Related papers
No related papers recorded.