Estrone sulfate stimulates growth of nitrosomethylurea‐induced breast carcinoma in vivo in the rat
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Summary
The ability of exogenously administered estrone sulfate to stimulate growth of a carcinogeninduced, hormone‐dependent rat mammary tumor is examined and the rate of conversion of estrone sulphate to free estrone and estradiol is measured to support the possibility that estron sulfate may serve as an important source of tumor tissue est radiol.
- Type
- article
- Published
- 1990-07-15
- Cited by
- 30
- References
- 30
- OpenAlex
- https://openalex.org/W1966332474
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36246924
Keywords
Estrone, Estrone sulfate, Estrogen, Endocrinology, Internal medicine
References
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- Steroid sulfatase and 17 beta-hydroxysteroid oxidoreductase activities in mouse tissues.
- Effects of plasma estrogen sulfates in mammary cancer cells.
- The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue.
- Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women.
- Estrone and estradiol content in human breast tumors: relationship to estradiol receptors.
- Plasma estrone-sulfate assessment of reduced estrogen production during treatment of metastatic breast carcinoma
- in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione
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- Enzymatic Control of Estrogen Production in Human Breast Cancer: Relative Significance of Aromatase versus Sulfatase Pathways
- Endogenous C19-steroids and oestradiol levels in human primary breast tumour tissues and their correlation with androgen and oestrogen receptors.
- Polyethylene glycols as solvents in implantable osmotic pumps.
- Effects of seven different oestrogen sulphates on uterine growth and on progesterone receptor in the foetal uterus of guinea pig after administration to the mother.
- 17β‐HYDROXYSTEROID DEHYDROGENASE AND AROMATASE ACTIVITY IN BREAST FAT FROM WOMEN WITH BENIGN AND MALIGNANT BREAST TUMOURS
- Effect of tamoxifen and alpha-difluoromethylornithine on clones of nitrosomethylurea-induced rat mammary tumor cells grown in soft agar culture.
Cited by
- Inhibition of oestrogen synthesis in postmenopausal women with breast cancer.
- Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
- Physiological and biochemical factors responsible for boar taint
- Rôle émergent des oestrogènes dans le cancer de la prostate : sulfate d'oestrone : marqueur de l’agressivité tumorale
- Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.
- Aromatase Inhibitors: Clinical Pharmacology and Therapeutic Implications in Breast Cancer
- Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction.
- The selective estrogen enzyme modulator (SEEM) in breast cancer.
- Regulation of oestradiol 17β hydroxysteroid dehydrogenase in breast tissues: The role of growth factors
- Evidence of in situ estrogen synthesis in nitrosomethylurea-induced rat mammary tumors via the enzyme estrone sulfatase.
- Oestrone sulphatase activity in mammary tumours and the liver of N-nitrosomethylurea treated rats.
- The development of steroid sulphatase inhibitors
- The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity.
- Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol.
- Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa).
- Steroid sulfatase: molecular biology, regulation, and inhibition.
- Determinants of tissue estradiol levels and biologic responsiveness in breast tumors
- Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF‐7 cell cultures
- In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone‐3‐O‐sulphamate
- In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma.
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