Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women.
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Summary
DHEA(S) may constitute a mechanism by which these androgens stimulate cancer growth and a rationale (besides suppression of estrogen precursors) for medical or surgical adrenalectomy in hormone sensitive metastatic mammary cancer.
- Type
- article
- Published
- 1986-04-01
- Cited by
- 249
- References
- 62
- OpenAlex
- https://openalex.org/W2014341557
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24809242
Keywords
Aromatase, Estrone, Endocrinology, Internal medicine, Dehydroepiandrosterone
References
- Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures.
- Estrogen synthesis and estradiol binding by human mammary tumors.
- Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue.
- Serum androgens and estrogens in postmenopausal women with and without endometrial cancer.
- Maternal stress decreases steroid aromatase activity in brains of male and female rat fetuses.
- Failure of breast cancer cells in long-term culture to aromatize androstenedione.
- Sex hormone-binding globulin and estrogen receptor in breast cancer: technique and preliminary clinical results.
- Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma.
- The endogenous concentration of estradiol and estrone in normal human postmenopausal endometrium.
- Estrone interaction with the rat uterus: in vitro response and nuclear uptake.
- Letter: The new N.H.S. consultant contract.
- In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway.
- Plasma concentration gradient of steroid hormones across human mammary tumours in vivo.
- Oestrogen receptors and metabolism of oestrone sulphate in human mammary carcinoma.
- Letter: Blood, plasma, or serum?
- Comparison of levels of cytosol estrogen receptors with "arterial" and "venous" concentrations of gonadic steroids in mammary tumors.
- Inhibition of 17 beta-hydroxysteroid dehydrogenase activity in human endometrium by adrenal androgens.
- Aromatization of testosterone and oestrogen receptor levels in human breast cancer.
- Effects of plasma estrogen sulfates in mammary cancer cells.
- Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography.
Cited by
- Inhibitory action of androstenedione on the proliferation and cell cycle kinetics of aromatase-free MXT and MCF-7 mammary tumour cell lines.
- Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
- Alteration of oestradiol metabolism in myc oncogene-transfected mouse mammary epithelial cells.
- Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies.
- Aromatase Inhibitors and Inactivators for Breast Cancer Therapy
- Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells
- Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics.
- Norelgestromin as selective estrogen enzyme modulator in human breast cancer cell lines. Effect on sulfatase activity in comparison to medroxyprogesterone acetate.
- Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies.
- Estrogen-induced breast oncogenesis: modulation by an Aurora kinase inhibitor.
- Regulation of estrogen action: role of 17 beta-hydroxysteroid dehydrogenases.
- Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast
- Angiogenesis regulation in hormone dependent breast- and ovarian cancer
- Growth factor activation of ErbB2/ErbB3 signaling pathways regulate the activity of Estrogen Receptors (ER)
- Radiolabeled estradiol derivatives to predict response to hormonal treatment in breast cancer: a review
- Phytochemicals for breast cancer prevention by targeting aromatase.
- Novel compounds inhibit estrogen formation and action.
- 4-hydroxy estradiol-induced oxidant-mediated signaling is involved in the development of breast cancer
- Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
- Human 17 beta-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression.
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