Plasma exchange, but not extracorporal recirculation nor removal of white blood cells, depresses plasma levels of IL-1 during severe gram-negative septicemia
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Summary
A biphasic IL-1 release occurs during early gram-negative septicemia, and it is possible to reduce these elevated IL- 1 levels by plasma exchange, this is associated with improved cardiovascular status and prolonged survival.
- Type
- article
- Published
- 1993-04-01
- Cited by
- 3
- References
- 14
- OpenAlex
- https://openalex.org/W1966326350
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:70364102
Keywords
Leukapheresis, Basal (medicine), Chemistry, Blood plasma, White blood cell
References
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- Meningococcal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exchange.
- Continuous removal of leucocytes during early gram-negative septicemia reduces plasma levels of endotoxin and improves cardiac performance.
- Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.
- Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
- Effects of murine recombinant interleukin 1 alpha on the host response to bacterial infection.
- Increased plasma levels of endotoxin and corresponding changes in circulatory performance in a porcine sepsis model: the effect of antibiotic administration.
- Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
- Plasma exchange performed during severe Gram negative septicemia: the influence on circulatory performance, plasma levels of endotoxin and bacterial counts in blood
- The influence of plasma exchange on shock mediators in septicemia
- STUDIES ON THE PATHOGENESIS OF FEVER
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