The Mouse APLP2 Gene
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Summary
The lack of a TATA box, the presence of a high GC content, and multiple transcription start sites place the APLP2 promoter in the class of promoters of “housekeeping genes.”
- Type
- article
- Published
- 1995-10-27
- Cited by
- 18
- References
- 2
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966268002
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11335979
Keywords
Biology, Molecular biology, Gene, TATA box, Promoter
References
- Genetics and probability in animal breeding experiments: a primer and reference book on probability, segregation, assortment, linkage and mating systems for biomedical scientists who breed and use genetically defined laboratory animals for research
- Development and applications of a molecular genetic linkage map of the mouse genome
- Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein
Cited by
- The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9
- Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.
- An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells.
- Increased gene expression of β-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid
- Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
- Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
- Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element.
- Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.
- Presenilin-1, amyloid precursor protein and amyloid precursor-like protein 2 mRNA levels in human superior frontal cortex during aging.
- It all sticks together—the APP-related family of proteins and Alzheimer's disease
- Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family.
- Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.
- The β-Amyloid Precursor Protein and its Derivatives: From Biology to Learning and Memory Processes
- and Alzheimer's disease
- Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
- Investigations of age- and plaque-related learning deficits in PDAPP mice and evaluations of anti-amyloidosis strategies on amyloid precursor protein transgenic mice
- The Function of the Amyloid Precursor Protein Family
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