ER quality control: the cytoplasmic connection.
Explore this paper's citation graph
Summary
These results suggest that at least the early steps of translocation are reversible, and the role of ER-bound proteasomes in dislocation and degradation of lumenal and membrane proteins is an important area for future investigation.
- Type
- review
- Published
- 1997-02-21
- Cited by
- 543
- References
- 20
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965901600
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6285591
Keywords
Endoplasmic reticulum, Biology, Cell biology, Secretory pathway, Endosome
References
- Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin‐proteasome pathway.
- Interaction of ascorbate and alpha-tocopherol in resealed human erythrocyte ghosts. Transmembrane electron transfer and protection from lipid peroxidation.
- Endocytosis and intracellular sorting of ricin and Shiga toxin
- Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae.
- Occurrence and biological roles of 'proximal glycanases' in animal cells.
- Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
- Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
- A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
- ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway
- Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.
- Degradation of CFTR by the ubiquitin-proteasome pathway.
- Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity*
- The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process.
- Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
- Protein degradation in the endoplasmic reticulum.
- ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase
- Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm
- Quality control in the secretory pathway.
- The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.
- Structure and functions of the 20S and 26S proteasomes.
Cited by
- Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease.
- Compartment-specific functions of the ubiquitin-proteasome pathway.
- A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.
- Molecular characterization of coagulation factor XII deficiency in a Japanese family
- E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.
- Inhibition of the 20S proteosome by a protein proteinase inhibitor: evidence that a natural serine proteinase inhibitor can inhibit a threonine proteinase.
- Quality Control: Proteins and Organelles
- Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome
- GFP-labelling of 26S proteasomes in living yeast: insight into proteasomal functions at the nuclear envelope/rough ER
- Treatment of Human Fibroblasts Carrying NPC1 Missense Mutations with MG132 Leads to an Improvement of Intracellular Cholesterol Trafficking.
- Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.
- Natural substrates of the proteasome and their recognition by the ubiquitin system.
- Potassium channels: some assembly required.
- Immunological functions of the proteasome.
- Mutational analysis of the role of GXXXG motif in the function of human organic anion transporter 1 (hOAT1)
- The molecular and biochemical characterisation of venom proteins from the box jellyfish, Chironex fleckeri
- Hepatitis E Virus: Molecular Mechanisms and Opportunities for Diagnostics
- Factor XII Tenri, a novel cross-reacting material negative factor XII deficiency, occurs through a proteasome-mediated degradation.
- Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.
- The Role of Dileucine in the Expression and Function of Human Organic Anion Transporter 1 (hOAT1)
Related papers
- Parotid Secretory Granules: Crossroads of Secretory Pathways and Protein Storage
- Pitfalls and opportunities in the characterization of unconventionally secreted proteins by secretome analysis.
- Multistep processing of the secretion leader of the extracellular protein Epx1 in Pichia pastoris and implications for protein localization.
- Non-classical Secretory Pathway
- Secretory lysosomes
- Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage
- Dual protein trafficking to secretory and non-secretory cell compartments: clear or double vision?
- The Roles of Endo-Lysosomes in Unconventional Protein Secretion