Klinefelter’s Syndrome, 47,XXY, in Male Systemic Lupus Erythematosus Supports a Gene Dose Effect from the X Chromosome

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Summary

These data are the first to associate Klinefelter's syndrome with an autoimmune disease found predominantly in women, and the risk of SLE in Klinefelter's syndrome is predicted to be similar to the risk in normal 46,XX women and ~14-fold higher than in 46,XY men, consistent with SLE susceptibility being partly explained by a X chromosome gene dose effect.

Type
article
Published
2008-08-01
Cited by
376
References
41
Access
Open access

Keywords

Klinefelter syndrome, Medicine, Population, Internal medicine, Immunology

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