Klinefelter’s Syndrome, 47,XXY, in Male Systemic Lupus Erythematosus Supports a Gene Dose Effect from the X Chromosome
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Summary
These data are the first to associate Klinefelter's syndrome with an autoimmune disease found predominantly in women, and the risk of SLE in Klinefelter's syndrome is predicted to be similar to the risk in normal 46,XX women and ~14-fold higher than in 46,XY men, consistent with SLE susceptibility being partly explained by a X chromosome gene dose effect.
- Type
- article
- Published
- 2008-08-01
- Cited by
- 376
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965381235
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1594322
Keywords
Klinefelter syndrome, Medicine, Population, Internal medicine, Immunology
References
- Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome.
- Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus.
- Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome.
- T cell abnormalities in mixed connective tissue disease complicated with Klinefelter's syndrome.
- Frequency of monosomy X in women with primary biliary cirrhosis.
- Klinefelter's syndrome accompanied by mixed connective tissue disease and diabetes mellitus.
- Letter: S.L.E. and Klinefelter's syndrome.
- The importance of estrogens in systemic lupus erythematosus.
- Carcinoma of the male breast: report of a series of 88 cases.
- Letter: S.L.E. and Klinefelter's syndrome.
- The prevalence and incidence of systemic lupus erythematosus in Birmingham, England. Relationship to ethnicity and country of birth.
- AUTOANTIBODIES IN CHROMATIN-POSITIVE MEN
- Causes of death in X chromatin positive males (Klinefelter's syndrome).
- 47 XXY/46 XY mosaic Klinefelter's syndrome presenting with multiple endocrine abnormalities.
- Profile of sex hormones in male patients with systemic lupus erythematosus
- The coincidence of Klinefelter's syndrome and systemic lupus erythematosus.
- Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
- Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Århus, Denmark
- The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome
- Baseline characteristics of a multiethnic lupus cohort: PROFILE
Cited by
- Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X
- Intercellular competition and levels of development: The plasticity of inevitability
- Immune Senescence, Epigenetics and Autoimmunity
- Genetic Risk Factors for Systemic Lupus Erythematosus : From Candidate Genes to Functional Variants
- Lupus: an overview of the disease and management options.
- Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity
- Pathogenese des systemischen Lupus erythematodes
- GENETIC STUDIES ON FINNISH LUPUS ERYTHEMATOSUS PATIENTS WITH CUTANEOUS MANIFESTATIONS
- Regulation of Type I Interferon Production in Plasmacytoid Dendritic Cells : Effect of Genetic Factors and Interactions with NK Cells and B Cells
- The Role of Gender in Uveitis and Ocular Inflammation
- Gene polymorphisms in SLE
- The immune response to cytomegalovirus and Epstein-Barr virus in systemic lupus erythematosus
- Epigenetics and Systemic Lupus Erythematosus: Unmet Needs
- Rheumatic diseases and Klinefelter's syndrome
- Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study
- What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation
- Klinefelter’s syndrome (47,XXY) among men with systemic lupus erythematosus
- Immunological Differences in Women Compared with Men: Overview and Contributing Factors
- X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women
- Age differences in Glucocorticoid Sensitivity of Inflammatory Cytokine Production Before and After stress
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