The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update
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Summary
It is assumed that susceptibility genes along with lifestyle risk factors contribute to the causation of the age-related sporadic Alzheimer disease (type II), and the desensitization of the neuronal insulin receptor similar to not-insulin dependent diabetes mellitus may be of pivotal significance.
- Type
- review
- Published
- 2002-03-01
- Cited by
- 213
- References
- 137
- OpenAlex
- https://openalex.org/W1964964168
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23729853
Keywords
Context (archaeology), Insulin, Insulin receptor, Disease, Alzheimer's disease
References
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- Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans.
- The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance
Cited by
- The role of diet in cognitive decline
- Effects of Fibrillar Aβ1–40 on the Viability of primary Cultures of Cholinergic Neurons and the Expression of Insulin Signaling–Related Proteins
- High- and low-spin Fe(III) complexes of various AGE inhibitors.
- Defensive Effect of Lansoprazole in Dementia of AD Type in Mice Exposed to Streptozotocin and Cholesterol Enriched Diet
- Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes
- Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.
- IS BRAIN AMYLOID PRODUCTION A CAUSE OR A RESULT OF DEMENTIA OF THE ALZHEIMER TYPE?
- Alterações neurogliais em ratos expostos ao ácido ocadáico como modelo de demência
- Memory Function and Brain Glucose Metabolism
- Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology
- Metabolic Syndrome
- Macronutrients, aluminium from drinking water and foods, and other metals in cognitive decline and dementia
- Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
- An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease
- Aberrant insulin signaling in Alzheimer's disease: current knowledge
- Changes in cortical acetyl‐CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG‐saporin
- Brain Insulin: Regulation, Mechanisms of Action and Functions
- Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
- Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease
- Insulin Resistance and Executive Dysfunction in Older Persons
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